2008

Paracellular Drug Delivery Through Baker’s Yeast Microcapsules

Yeast has the ability to reversibly open up the junctions between cells to aid drug delivery. By micro-encapsulating active ingredients inside the yeast cells, this technology enhances paracellular movement of active ingredients in mucus-rich areas such as buccal, oral, nasal, vaginal, anal, and others. Application could be by means of powder, tablet, capsule, chewable tablet, chewing gum, melting film strip, spray, cream, or gel. Yeast offers an alternative to chitosan as a permeation enhancer and mucoadhesive mechanism.

It may also be possible to have a multi-drug system where a water-soluble active ingredient, formulated together with yeast cells, also has a lipophilic/water-insoluble active ingredient entrapped within those yeast cells. The technology offers new modalities for oral mucosal drug delivery; targeted delivery of a lipophilic active anywhere from the mouth to the lower bowel; topical delivery; taste-masking of volatile lipophilic flavors; better uptake in creams, gels, and ointments; improved nasal spray drug delivery; and non-invasive insulin delivery.

Get the complete report on this technology at:
www.techbriefs.com/tow/200806b.html
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: 781-972-0600

White Papers

Changing Face of Robotics
Sponsored by Maplesoft
Getting the Most Out Of Your Next Generation Digital Security Surveillance System
Sponsored by Adlink Technology
Oscilloscope Fundamentals Primer
Sponsored by Rohde and Schwarz
Linear Motors Application Guide
Sponsored by Aerotech
Specifying Actuators for Heavy-Duty Packaging Applications
Sponsored by Rollon
Improving Absorption Measurements through Light Source Selection
Sponsored by Ocean Optics

White Papers Sponsored By: