2010

Size-Controlled Fabrication of Microparticles Incorporating Active Ingredients

A scaleable technique based on ink-jet technology fabricates polymer microparticles with best-in-class size distribution. It is suitable for a variety of particle morphologies such as solid, porous, and microcapsules filled with gases, liquids, or a combination. Drugs or active ingredients can be incorporated in solid or liquid form. The monodispersity of the particles ensures excellent control of both the dose and the site/nature of delivery of the active ingredient.

The technique uses an ink-jet head submerged in an aqueous phase to form the micron-sized polymer droplets, drop-by-drop, from a polymer emulsion feedstock. Solid particles are then extracted from the solution. The particle size can be accurately predicted from the initial polymer drop size (controlled by the ink-jet head) and the polymer concentration.

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