New home-use and point-of-care diagnostic medical technologies are needed. The diagnostics kits should monitor diseases not easily measured. Testing may be done within the device, or the device may be a tethered testing head that reports to a central diagnostics facility. The product can be tethered via phone, cell phone, or Internet, for example. A sample may also be prepared by the device and physically delivered to a central testing service. Areas of interest include cardiac, cholesterol, digestive health, lung function, osteoporosis, and progressive neuropathy.