Regulating Glucose and pH, and Monitoring Oxygen in a Bioreactor

Glucose and oxygen concentrations are monitored, and glucose concentration and pH are adjusted as needed.

Figure 1 is a simplified schematic diagram of a system that automatically regulates the concentration of glucose or pH in a liquid culture medium that is circulated through a rotating-wall perfused bioreactor. Another system, shown in Figure 2, monitors the concentration of oxygen in the culture medium.