Nematodes are among the most damaging crop pests. Very few available chemical nematicides can affect control, and some options are restricted by the Environmental Protection Agency and similar bodies. Nematodes damage plant roots, and reduce the plant’s ability to take up water and nutrients. The need is great to discover less toxic, and more environmentally acceptable, chemical substitutes for the current suite of commercial nematicides. Successful technologies must demonstrate efficacy against nematodes or nematode damage to plants, provide at least benchtop data to support efficacy claims, and display new and/or multiple modes of action.