- Created on Tuesday, 01 May 2007
A flexible, platform microencapsulation technology can be applied to actives from water soluble to water insoluble materials at the 20–35% range; loading levels of up to >50% have been achieved for some actives. The microcapsules protect the actives from environmental conditions, and can be designed to release their core materials in a controlled manner over a designated period of time or by a trigger (temperature, etc.). The capsules can be designed to have multiple cores that can either be contained throughout the inner core of the capsule or seeded in the shell (or both). These “seeded” microcapsules could be used in abuse-resistant pharmaceutical formulations, and could also be applied in a tableting process. The technology increases the bioavailability of pharmaceuticals difficult to formulate and can solubilize them.
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