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Intranasal Scopolamine — INSCOP

This drug, in intranasal form, is an effective treatment for motion sickness. Lyndon B. Johnson Space Center, Houston, Texas Space motion sickness (SMS) commonly experienced by astronauts during a space mission often requires treatment with medication. However, exposure to a microgravity environment results in a myriad of physiological changes that alter bioavailability. In particular, studies indicate that the bioavailability of oral scopolamine (SCOP) is decreased during spaceflight. Although altered gastrointestinal function, including delayed gastric emptying, appears to contribute to decreased bioavailability of oral medications, other factors typical of spaceflight may influence the pharmacokinetics of medications administered via a variety of other non-parenteral routes.

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Microbial Isolates from Research Activities as a Biological Resource

A collection of 1,530 individual isolates is used to evaluate the potential hazard of introducing sterilization-resistant microorganisms onto planetary spacecraft. NASA’s Jet Propulsion Laboratory, Pasadena, California International treaty requires spacecraft landing on planetary surfaces that may have water present, or may have supported life in the past, to adhere to strict guidelines governing the microbial contaminants that are incidentally present in, and on, spacecraft hardware introduced to those environments. Precautions to prevent microbial contamination of flight hardware are taken throughout assembly, test, and launch operations to minimize transferring biological contamination to the planet. Effectiveness of these precautions is assessed by conducting bioassays of spacecraft surfaces and assembly areas to estimate the number of microorganisms present. Microorganisms discovered are preserved as a living document and compendium for the mission. The organisms that are of greatest concern are those that are highly resistant to desiccation and spacecraft sterilization by dry heat.

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Chromatid Painting for Chromosomal Inversion Detection

Applications include clinical cytogenetics, biomedical research, and biodosimetry. Lyndon B. Johnson Space Center, Houston, Texas Chromosomal inversions, such as those occurring following exposure to ionizing radiation, are especially difficult to detect by current techniques. Therefore, their true frequency and importance have been underappreciated. Even the impressive technology of whole genome sequencing, which is becoming more readily and rapidly available, is useless for the detection of many chromosomal rearrangements within a chromosome. Likewise, stateof- the-art cytogenetic mBAND analysis of irradiated normal human tissue can only occasionally reveal radiationinduced inversions. A novel and innovative approach called differential Genomic Hybridization (dGH) or chromatid painting has been developed to further explore, expand, and capitalize on this new frontier of molecular cytogenetics.

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Guidelines for Meal Replacement Bars in a Space Food System

Emergency relief organizations, food banks, the military, and food service markets all have use for the bars due to their nutritional offering and long shelf life. Lyndon B. Johnson Space Center, Houston, Texas To decrease the mass of the space food system and still maintain the nutritional intake of a mission crew, meal replacement bars and beverages are desired to supplement the menu and serve as meal alternatives. Nutritional requirements for such replacement products for breakfast and lunch have been established based on the current nutritional delivery of the International Space Station standard menu.

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Selective Access and Editing in a Database

Ames Research Center, Moffett Field, California A complex organization with many tasks and sub-tasks, many phases, and many workers often will have an associated database with many users and groups, each of whom has a limited “need to know” (e.g. fine-grained security access controls) that does not extend to all information in the database. A group of users having access to information in a particular portion of the database may need to edit one or more documents to restate the original information more conveniently or accurately.

Posted in: Briefs, TSP, Electronics & Computers

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Integrated Science Instrument Module (ISIM) Reconfigurable Packet Tool

Goddard Space Flight Center, Greenbelt, Maryland This tool supports the development of table loads required to inform the flight software of new on-the-fly packet definitions. The main outcome of the processing includes all the database products needed by the ground system to process the newly created packets. The tool ingests the latest telemetry definition from the James Webb Space Telescope (JWST) central database repository, and updates those definitions as required to support the dynamic packet definitions determined by the user of the tool. These updated telemetry definitions are in a form that can be directly sent to the JWST central database repository for inclusion in a new database version. The tool allows for the inclusion in the new packet definitions of any ISIM Flight Software (FSW) data types.

Posted in: Briefs, TSP, Electronics & Computers

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Bug View

Ames Research Center, Moffett Field, California This hardware-independent, Web-based service provides the capabilities to improve software assurance by streamlining the management of the analysis tools, the code being analyzed, and the results that are generated. The service is a GUI (graphical user interface) application that addresses the needs of software developers and supporting analysts by presenting a single interface from which multiple static code analysis tools can be configured and executed. It also provides the means to automate consistent periodic analysis of each release of code, has the capability to track code change and identified issues in the code through progressive build releases, and provides tools for identifying and rejecting false-positives from results while identifying quickly what the real issues are within the source code.

Posted in: Briefs, Electronics & Computers

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