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A Simplified Production of Organic Compounds Containing High Enantiomer Excesses

NASA has developed a novel approach for producing sugars and sugar acids enriched with one of the two enantiomers of individual compounds. This approach can also be adapted for other compounds, such as amino acids. All objects, including chemical compounds, have mirror images, some of which cannot be superimposed. In the case of chemical compounds, these non-superimposable mirror images are called enantiomers and are widely used in biological processes. NASA’s method produces high enantiomer excesses from simple and relatively inexpensive precursors (formaldehyde and simple salts) and hardware components without the need and expense of using (at some stage) biological sources. Unlike the commercial production of most rare enantiomers, this innovation employs conditions that are extremely common, non-biological, and relatively inexpensive to set up.

Posted in: Briefs, Medical

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Generation of High-Pressure Oxygen Via Electrochemical Pumping in a Multi-Stage Electrolysis Stack

Innovators at NASA’s Glenn Research Center have developed a method for producing pure high-pressure oxygen via an electrochemical pumping process through a solid oxide electrolysis (SOE) cell stack. Glenn’s device can either concentrate the oxygen in the ambient atmosphere or extract the oxygen via the chemical reduction of carbon dioxide, water, or any combination of these substances. This solid-state device does not use any moving parts or any extra separation processes to purify the delivered oxygen. Instead, Glenn’s technology relies on a multi-stage stack design and an SOE process that includes an oxygen-ion-conducting ceramic membrane to generate high-pressure oxygen within a compact, noiseless device. This process has great potential for use in medical, industrial, and recreational applications.

Posted in: Briefs, Medical

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Tension Distribution in Tendon-Driven Fingers

The technology can be used in telemedicine, surgical robotics, home medical service robotics, medical rehabilitation, and hospital service robotics. Researchers at the NASA Johnson Space Center (JSC), in collaboration with General Motors and Oceaneering, have designed a state-of-the-art, highly dexterous, humanoid robot called Robonaut 2 (R2). R2 is made up of multiple component technologies and systems encompassing nearly 50 patented and patent-pending technologies with the potential to be game-changers in multiple industries, including the medical industry. R2 technologies can aid in a variety of medical applications, ranging from telemedicine to handling the logistics of medical procedures. These activities can be done in autonomous mode or in teleoperation mode, where the robot is controlled by a technician or physician. This type of operation would be advantageous in situations where a biomedical hazard poses risks to humans, such as a contagious outbreak or a combat situation. For more routine daily use, R2 could function as an assistant to the hospital staff.

Posted in: Briefs, Medical

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Rapid Polymer Sequencer

Solid-state nanopore-based analysis of nucleic acid polymers is revolutionary. No other technique can determine information content in single molecules of genetic material at speeds of 1 subunit per microsecond. Since individual molecules are counted, the output is intrinsically quantitative. The nanopore approach is more generalized than any other method and may be used to analyze any polymer molecule, applying nanofabrication, nanoelectronic components, and high-speed signal acquisition. Geometry of the solid-state nanopore (less than 5 nm in length and 5 nm in diameter) will enable 1-5 nucleotide resolution measurements. This means that maximum resolution will be improved by 100-fold compared to biological ion-channel measurements. The solid-state nanopore sensor will permit sequencing DNA at a much faster rate, along with analyzing electronic properties of individual subunits of DNA or RNA, to obtain linear composition of each genetic polymer molecule.

Posted in: Briefs, Medical

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Life Sciences Guidebook: Best Practices for FDA Compliance Solutions

In a market where high-demand causes organizations to seek software systems that will fit into their complex business infrastructure, the pressure to find the right system often causes angst to many. Learn some of the key elements to spotting a good FDA Compliance solution, techniques for achieving GMP Compliance, and how to ensure that Quality and Compliance are met in the Life Science industry.

Posted in: White Papers, White Papers, FDA Compliance/Regulatory Affairs, Software

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Evaluation of Platelet Aggregation on Commonly-Used Blood-Contacting Medical Polymers

The blood compatibility of polymers used for medical devices which facilitate the movement or storage of blood is critical, particularly in devices whose applications where device-contacting blood will be re-introduced into a patient (dialyzer housings, storage vessels, IV components, etc.). Standard biocompatibility testing conducted in accordance with the ISO 10993 series of standards for these materials includes various tests for hemocompatibility1, including platelet interactions, but direct microscopic examination of platelet adhesion and activation is less common. This white paper presents the results of a scanning electron microscopic (SEM) examination of human platelet adhesion on polymeric materials, which shows that CYROLITE® materials may be less likely to aggregate and activate platelets than some other commonly-used blood-contacting materials.

Posted in: MDB, White Papers, White Papers, Bio-Medical, Medical

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How the Laser, Optic, & Photonic Industries Benefit from Electropolishing

Improve precision and cleanliness with an enhanced surface finish. Like other industries that utilize electropolishing to finish metal components, there are many benefits associated with electropolishing metal components used in photonics, optics or laser applications.

Posted in: White Papers, Coatings & Adhesives, Materials, Medical, Optics, Photonics

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