Enabling Microliquid Chromatography by Microbead Packing of Microchannels

The microbead packing is the critical element required in the success of onchip microfabrication of critical microfluidic components for in-situ analysis and detection of chiral amino acids. In order for microliquid chromatography to occur, there must be a stationary phase medium within the microchannel that interacts with the analytes present within flowing fluid. The stationary phase media are the microbeads packed by the process discussed in this work. The purpose of the microliquid chromatography is to provide a lightweight, low-volume, and low-power element to separate amino acids and their chiral partners efficiently to understand better the origin of life.

Posted in: Bio-Medical, Medical, Briefs

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On-Command Force and Torque Impeding Devices (OC-FTID) Using ERF

This technology is applicable as a rehabilitation or exercise device. Various machines have been developed to address the need for countermeasures of bone and muscle deterioration when humans operate over extended time in space. Even though these machines are in use, each of them has many limitations that need to be addressed in an effort to prepare for human missions to distant bodies in the solar system.

Posted in: Bio-Medical, Medical, Briefs

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RECOVIR Software for Identifying Viruses

Most single-stranded RNA (ssRNA) viruses mutate rapidly to generate a large number of strains with highly divergent capsid sequences. Determining the capsid residues or nucleotides that uniquely characterize these strains is critical in understanding the strain diversity of these viruses. RECOVIR (an acronym for “recognize viruses”) software predicts the strains of some ssRNA viruses from their limited sequence data. Novel phylogenetic-treebased databases of protein or nucleic acid residues that uniquely characterize these virus strains are created. Strains of input virus sequences (partial or complete) are predicted through residue-wise comparisons with the databases.

Posted in: Software, Medical, Briefs

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On-Command Force and Torque Impeding Devices (OC-FTID) Using ERF

This technology is applicable as a rehabilitation or exercise device. Various machines have been developed to address the need for countermeasures of bone and muscle deterioration when humans operate over extended time in space. Even though these machines are in use, each of them has many limitations that need to be addressed in an effort to prepare for human missions to distant bodies in the solar system.

Posted in: Bio-Medical, Rehabilitation & Physical Therapy, Treatment Devices, Medical, Briefs, MDB

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Intravenous Fluid Generation System

This system can be used in remote medical facilities where limitations such as lack of refrigeration may limit the type and volume of medical fluids being stored or transported. The ability to stabilize and treat patients on exploration missions will depend on access to needed consumables. Intravenous (IV) fluids have been identified as required consumables. A review of the Space Medicine Exploration Medical Condition List (SMEMCL) lists over 400 medical conditions that could present and require treatment during ISS missions.

Posted in: Bio-Medical, Medical, Briefs

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Detection of Only Viable Bacterial Spores Using a Live/Dead Indicator in Mixed Populations

This technology can be used by the food and pharmaceutical industries to validate sterility and quality. This method uses a photoaffinity label that recognizes DNA and can be used to distinguish populations of bacterial cells from bacterial spores without the use of heat shocking during conventional culture, and live from dead bacterial spores using molecular-based methods.

Posted in: Bio-Medical, Medical, Briefs

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Rapid Detection of Herpes Viruses for Clinical Applications

There are eight herpes viruses that infect humans, causing a wide range of diseases resulting in considerable morbidity and associated costs. Varicella zoster virus (VZV) is a human herpes virus that causes chickenpox in children and shingles in adults. Approximately 1,000,000 new cases of shingles occur each year; post-herpetic neuralgia (PHN) follows shingles in 100,000 to 200,000 people annually. PHN is characterized by debilitating, nearly unbearable pain for weeks, months, and even years. The onset of shingles is characterized by pain, followed by the zoster rash, leading to blisters and severe pain. The problem is that in the early stages, shingles can be difficult to diagnose; chickenpox in adults can be equally difficult to diagnose. As a result, both diseases can be misdiagnosed (false positive/negative).

Posted in: Bio-Medical, Medical, Data Acquisition, Briefs

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