Modifying Polyethylene Oxide for Melt-Processability

Water-soluble packaging, disposable articles, and transdermal patches are possible applications for products made using water-soluble PEO.

Generally, high-molecular-weight polyethylene oxide (PEO) can present processing challenges due to its high melt viscosity and poor melt drawability; it can be difficult to form into fine-gauge film or small-diameter fibers. There is the alternative technology of solution casting, which has occasionally been utilized to cast thin films; however, solution casting may not always be practical for large-scale, economically viable film production.

Posted in: Briefs, MDB, Briefs, Coatings & Adhesives, Materials, Bio-Medical, Medical, Casting, Materials properties, Resins
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Topical Compositions and Glove for Protection and Shielding Against Radiation Exposure

These technologies have applications in military, nuclear energy, and emergency preparedness.

Over the past several decades, there has been a proliferation of medical diagnostic and treatment devices that involve the use of X-rays, beta rays, gamma rays, and radioactive isotopes. In addition, there has been recent concern regarding possible radiation exposure from nuclear weapons and terrorist attacks on nuclear facilities. Thus, there is a need for devices that can protect areas of the body that may be exposed to damaging radiation without hindering the user’s dexterity or loss of touch sensation.

Posted in: Briefs, MDB, Briefs, Coatings & Adhesives, Materials, Bio-Medical, Medical, Patient Monitoring, Medical equipment and supplies, Protective clothing, Radiation protection
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Digital Microfluidics Sample Analyzer

Combined innovations enable portable analyzers for medical diagnostics, bioterrorism pathogen detection, and food supply analysis.

Three innovations address the needs of the medical world with regard to microfluidic manipulation and testing of physiological samples in ways that can benefit point-of-care needs for patients such as premature infants, for which drawing of blood for continuous tests can be life-threatening in their own right, and for expedited results. A chip with sample injection elements, reservoirs (and waste), droplet formation structures, fluidic pathways, mixing areas, and optical detection sites, was fabricated to test the various components of the microfluidic platform, both individually and in integrated fashion. The droplet control system permits a user to control droplet microactuator system functions, such as droplet operations and detector operations. Also, the programming system allows a user to develop software routines for controlling droplet microactuator system functions, such as droplet operations and detector operations.

Posted in: Briefs, MDB, Briefs, Coatings & Adhesives, Materials, Bio-Medical, Diagnostics, Medical, Patient Monitoring, Software, Microelectromechanical devices, Sensors and actuators, Diagnosis, Medical equipment and supplies, Product development, Test equipment and instrumentation
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Process to Selectively Distinguish Viable From Non-Viable Bacterial Cells

The combination of ethidium monoazide (EMA) and post-fragmentation, randomly primed DNA amplification technologies will enhance the analytical capability to discern viable from non-viable bacterial cells in spacecraft-related samples. Intercalating agents have been widely used since the inception of molecular biology to stain and visualize nucleic acids. Only recently, intercalating agents such as EMA have been exploited to selectively distinguish viable from dead bacterial cells.

Posted in: Briefs, MDB, Briefs, Bio-Medical, Medical, Bacteria, Test procedures, Spacecraft
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Radiation Protection Using Carbon Nanotube Derivatives

This technology can be used in clinical oncology and in nuclear disaster response.

BHA and BHT are well-known food preservatives that are excellent radical scavengers. These compounds, attached to single-walled carbon nanotubes (SWNTs), could serve as excellent radical traps. The amino-BHT groups can be associated with SWNTs that have carbolyxic acid groups via acid-base association or via covalent association.

Posted in: Briefs, Bio-Medical, Medical, Biological sciences, Human factors, Nanomaterials, Radiation protection
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Orthotic Dynamically Adjusts to Changes in Foot Structure and Movement

This orthotic insert mimics the experience of walking in wet sand.

Kinesthotic© orthotics are made to adapt to the foot by replicating, within footwear, an explicit quality of beach-sand surface dynamics on whatever surface the footwear is used. The resulting support complies with the biomechanically sound and functional supportive principles and demands of each foot. The proprietary semi-fluid One-MinuteFit© molding composite is hermetically sealed within the Kinesthotic retaining envelope aligned on top of the pre-molded dynamic molding chassis.

Posted in: Briefs, MDB, Briefs, Bio-Medical, Medical, Rehabilitation & Physical Therapy, Medical equipment and supplies, Molding, Biomechanics
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Reusable Personal Radiation Dosimeter for Ultraviolet or Radioactive Radiation

This inexpensive device is worn on clothing and is reusable.

Radiation dosimeters are important for people working with radioactive isotopes, as in analytical research laboratories, in nuclear medical applications, in medical X-ray imaging, in nuclear power-stations, or in non-destructive testing of materials by ionizing radiation. They need to know their received radiation dose and need to be warned when threshold values are exceeded. Another area where personal radiation doses are important is in the exposure to ultraviolet (UV) light (UV-A , UV-B, and UV-C). Dose detection can be helpful for skin protection and damage prevention.

Posted in: Briefs, MDB, Briefs, Bio-Medical, Medical, Patient Monitoring, Sensors and actuators, Radiation, Radiation protection
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High-Altitude Hydration System

Multiple methods of keeping water from freezing can be used by law enforcement personnel, skiers, and campers, and underwater by military personnel.

Three methods are being developed for keeping water from freezing during high-altitude climbs so that mountaineers can remain hydrated. Three strategies have been developed. At the time of this reporting two needed to be tested in the field and one was conceptual.

Posted in: Briefs, MDB, Briefs, Bio-Medical, Medical, Water, Human factors, Needs assessment, Research and development
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Eye, Ear, and Skin Scope

The handheld digital device has three attachable lenses for ear, eye, and skin imaging.

A handheld, digitized ophthalmo scope, otoscope, or dermoscope takes digital images and video, and transmits the images to patients’ electronic medical records and/or to physicians for remote diagnosis. The device can be used for retinal (ophthalmoscopy), ear (otoscopy), or skin (dermatoscopy) imaging.

Posted in: Briefs, MDB, Briefs, Bio-Medical, Diagnostics, Medical, Imaging and visualization, Diagnosis, Diseases, Medical equipment and supplies
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Enhancing Tumor Drug Delivery by Laser-Activated Vascular Barrier Disruption

Photodynamic therapy is used to eradicate tumor tissue and provide enhanced drug delivery.

An obstacle to successful cancer drug therapy is the existence of drug delivery barriers, which result in insufficient and heterogeneous drug delivery to the tumor tissue. This drug delivery problem not only limits the clinical application of existing chemotherapeutics, but also decreases the effectiveness of many new drugs under development. Photodynamic therapy (PDT), a modality involving the combination of a photo-sensitizer and laser light, is an established cancer therapy. This work demonstrates the effectiveness of vascular-targeting PDT in eradicating tumor tissue, and modifying vascular barrier function for enhanced drug delivery.

Posted in: Briefs, MDB, TSP, Briefs, TSP, Bio-Medical, Drug Delivery, Medical, Patient Monitoring, Lasers & Laser Systems, Photonics, Lasers, Cardiovascular system, Diseases, Medical equipment and supplies, Pharmaceuticals
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