Use of Osteoclast-Inhibiting Compounds to Prevent Radiation-Induced Bone Loss

Lyndon B. Johnson Space Center, Houston, Texas

This technology features a method for preventing or treating radiation-associated loss of bone mass, bone density, or bone strength in a subject. This technology involves administering to the subject an amount of anti-resorptive or osteoclast-inhibiting compound sufficient to prevent or mitigate loss of bone mass, density, or strength caused by radiation-associated increases in the number or activity of osteoclasts.

Posted in: Briefs, Medical, Medical, health, and wellness
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2015 Create the Future Design Contest: Grand Prize Winner

Non-Surgical Circulatory Support Device for the Treatment of Chronic Heart Failure

Omar Benavides, Benjamin Hertzog, Jace Heuring, Reynolds Delgado, and Will Clifton Procyrion, Inc. Houston, TX

Procyrion is developing the first catheter-deployed heart pump intended for long-term treatment of chronic heart failure. Thinner than a #2 pencil and only 6 cm long, Aortix™ has the potential to become a low-risk circulatory assist device for a broad range of patients.

Posted in: Articles, Aerospace, Medical, Design processes, Cardiovascular system, Diseases, Medical equipment and supplies, Product development
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2015 Create the Future Design Contest: Medical Category Winner

Smart X-ray Source

Mark Eaton Stellarray Austin, TX

“This recognition is most welcome, since the NASA Tech Briefs readership includes potential users of our technology. The smart x-ray source is a true platform technology with many applications, the latest being a digitally addressable research irradiator we believe will greatly increase productivity in radio biology and radio chemistry. We look forward to hearing from Tech Briefs readers about other ideas they might have for this versatile new tool.”Since the discovery of x-rays 110 years ago, affordable x-ray sources have all been point source x-ray tubes in which x-rays are generated at a single spot on an anode by a single electron beam accelerated at high voltage across a vacuum gap. Generation of x-rays from a single spot, even in rotating anode tubes, limits the flux they can deliver, because most of the e-beam energy will be absorbed in that spot.

Posted in: Articles, Aerospace, Medical, Design processes, Imaging and visualization, Diagnosis, Diseases, Medical equipment and supplies, Product development
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Risky Business: Why Excluding Suppliers from Your Quality Processes Could Cost You

Suppliers play a major role in bringing products to market. This means that the product received from suppliers must be of the highest quality and level of safety possible—this is a must because stakeholders not only rely on their suppliers to help bring products to market, they also rely on them to help maintain their brand image. In this White Paper, you'll learn how to incorporate suppliers into your quality and compliance activities, resulting in a greater level of assurance.

Posted in: White Papers, White Papers, Medical
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Polymerase Chain Reaction Preparation Kit and Self-Enclosed, Pipette-Free DNA/RNA Isolation Device

Other applications include situations involving the military and in cases where one has to perform PCR analysis in the field.

Lyndon B. Johnson Space Center, Houston, Texas

The ability to monitor and detect microorganism contamination/infection is important for long space voyages, in order to maintain a clean environment not only for the health of the astronauts, but also for electronics and structural materials. Technologies based upon the polymerase chain reaction (PCR) method have proven to be faster and more sensitive than traditional methods in diagnosis of microorganisms. The real-time PCR technique has been used on the ground to detect microorganisms in the samples collected on the International Space Station (ISS). However, the ability of using PCR to detect infectious agents rapidly and specifically in space is currently unavailable. The major technological blockade to the use of PCR in space is the lack of a hazard-free and microgravity compatible hardware for RNA/DNA isolation.

Posted in: Briefs, TSP, Medical, Medical, health, and wellness, Diagnostics, Test equipment and instrumentation, Spacecraft
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Hydrostatic Hyperbaric Oxygen Treatment Chamber

This system allows treatment of patients in remote locations.

Lyndon B. Johnson Space Center, Houston, Texas

A hyperbaric chamber has been designed to achieve the goals of maximizing safety, minimizing complexity, and minimizing cost of hyperbaric chamber therapy. This design minimizes the volume of compressed gas in the chamber, and eliminates the need for complex gas mixing, carbon dioxide scrubbing, thermal management, and fire suppression systems. The simple pressurization system affords safe operation by minimally trained personnel. It requires only clean water and small volumes of compressed oxygen, and uses no electrical power. These features allow the chamber to be used in remote, undeveloped locations where hyperbaric oxygen therapy is currently not feasible.

Posted in: Briefs, TSP, Medical, Medical, health, and wellness
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Reagent and Method of Using a Microfluidic Cytometer for Leukocyte Differential Count

The requirement for dilution is completely eliminated by specifically staining leukocytes.

Lyndon B. Johnson Space Center, Houston, Texas

Leukocytes respond to toxic, infectious, and inflammatory processes to defend tissues and eliminate disease process or toxic challenge. Accurate and prompt counting and differentiation of leukocytes is critical for diagnoses of infection, leukemia, or allergy; monitoring bone marrow function; or monitoring the body’s response to various treatments. White blood cell (WBC), or leukocyte, differential count is a clinical analysis that numerates the total number of leukocytes in per volume blood, and classifies leukocytes into different types, such as lymphocytes, monocytes, neutrophils, eosinophils, and basophils.

Posted in: Briefs, TSP, Medical, Medical, health, and wellness
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Intravehicular Tissue Equivalent Proportional Counter (TEPC) Flight Software

TEPC is used to make operational radiation protection decisions.

Lyndon B. Johnson Space Center, Houston, Texas

The ISS (International Space Station) Medical Operations Requirements Document (MORD) establishes the medical support requirements for ionizing radiation exposure, including common dose limits, radiation monitoring, recordkeeping, and management of radiation exposure through As Low As Reasonably Achievable (ALARA) practices through all mission phases. The dynamic, complex, and unique nature of the radiation environment in low Earth orbit is such that radiation health and protection requirements rely upon analytical modeling and continuous measurements of the onboard environment, as well as personal dosimetry that includes analytical assessments of passive dosimeters worn at all times by each crewmember. External radiation detection instruments are necessary to provide near-real-time information about the dynamic radiation environment experienced by crewmembers during EVA (extravehicular activity). Active radiation area monitoring on ISS is necessary to provide continuous information to ground controllers and to the crewmembers for the purpose of maintaining crew exposures below limits and in accordance with ALARA practices.

Posted in: Briefs, Medical, Computer software and hardware, Medical, health, and wellness, Spacecraft
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Wet Waste Drying Bag

Ames Research Center, Moffett Field, California

This invention facilitates collection, storage, concentration, and drying of liquid or mixed liquid/solid waste material. The invention may serve as a portable toilet or may be used to dry biological specimens or concentrate water samples for analysis. It can replace diapers, special plastic bags, and airflow waste disposal systems used in space missions. The resulting products are clean, but not potable, water and dried, compacted, bagged material that may be human waste or other matter. The bag simplifies collection and reduces disposal cost.

Posted in: Briefs, Medical, Waste management, Medical, health, and wellness, Spacecraft
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Combinatorial Multidomain Mesoporous Chips for Fractionation of Biomolecules

The chips can operate with extraordinary rapidity without sample pre-processing.

Lyndon B. Johnson Space Center, Houston, Texas

A promising strategy of early diagnosis is the detection of biological signatures (molecular biomarkers) from readily available body fluids, such as blood. However, the onset of most human diseases cannot be univocally identified on the basis of a single biomarker. Considerable attention has been devoted to the development of proteomic methods for the quantitative and simultaneous detection and identification of “signature profiles” constituted by multiple protein and peptide biomarkers using mass spectrometry (MS). A critical aspect of the development of MS-based proteomics and peptidomics is the extraordinarily broad assortment of molecular species in blood, with concentrations ranging over more than ten orders of magnitude. This dynamic complexity limits the detection of disease-related peptides present in trace amounts within a large background of very abundant and non-relevant proteins.

Posted in: Briefs, Medical, Medical, health, and wellness, Diagnostics, Test equipment and instrumentation
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