Using multiple principles of olfactory system function and libraries of broadly responding sensors enable devices to be tailored to different odor-detection problems.

Since 9/11, we are increasingly threatened by terrorist plots — the release of noxious substances into crowded public places or on airplanes, in crowded buildings, and in sports arenas. Anxieties about these rare events are mostly unrealized, but such events have occurred frequently enough — such as in Madrid, London, or Delhi — that protective measures that will reassure the public are needed. To be effective, sensors and screening devices must be deployed widely, be inexpensive, support high-volume throughput (respond rapidly), and be available for a wide range of threats (i.e., flexible and adaptable to different or new scenarios).

Given these scenarios, devices are needed that identify defined chemical targets, yet at the same time, remain flexible enough to respond to rapid shifts in terrorist tactics employing new explosive and toxic materials. Selectivity based on sensitivity to single chemical attributes such as differential retention on a chromatographic column, allows sorting in one dimension, whereas selectivity based on multiple chemical attributes can enable devices to identify more “components” or compounds with fewer sensors.

The use of sensors that can examine multiple chemical attributes, thereby allowing discrimination across a number of different dimensions, can be engineered in various ways. For example, in the case of gas chromatography (GC), this can be implemented by using multiple, different columns; in ion mobility spectroscopy (IMS), this can be implemented by testing for both positive and negative ions; and in electronic noses, this approach can be exploited by incorporating overlapping, broadly selective sensors. Detection and identification may be augmented by using parameters that include the time course and amplitude of the response. The more flexibility in the dimensionality of detection space, the greater the ability of an analytical device to detect and identify multiple disparate compounds.

(A) Portable configuration of the ScenTraK™, a Handheld Optoelectronic Platform that models the way biological noses work to detect, identify, and discriminateairborne compounds. This production prototype accepts replaceable cartridges, with space available for mounting networking transceivers or other devices near the snout at the left. (B) Exploded, schematic view of the ScenTraK™ sensor chamber and airflow path.