Health, Medicine, & Biotechnology

Low Friction Plastic Technology For Single-use Drug Delivery Devices

Start-up coefficient of friction and stick-slip (or “stiction”) elimination are dominant performance drivers in single-use drug delivery devices that have moving parts. RTP Company has completed a rigorous investigation that establishes and defines a new friction test to measure and compare plastic-against-plastic friction behavior that occurs at initial startup. This new test uses forces and speeds that characterize the action of injection pens, auto-injectors, stop cocks, inhalers, safety syringes and other devices. This paper describes the newly created friction test method, and its core data point known as Glide FactorSM, as well a series of tests to compare the friction behavior of select polymers and internal lubricants for use in single-use drug delivery devices. The use of internally lubricated plastics can eliminate costly secondary operations to apply a topical lubricant, reduce the total amount of silicone that reaches the patient via the device, and improve the overall quality of the device. The goal of this paper is to share a tribological database that enables device designers to screen plastic-on-plastic friction pairs to optimize safe and effective material selections.

Posted in: White Papers, White Papers, Coatings & Adhesives

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How to Prevent Step Losses with Stepper Motors

While stepper motors are an excellent solution for many applications, a key concern is step losses. However, in most instances step losses can be prevented or corrected. It is important to remember that a stepper motor does not operate like a DC motor. This white paper from MICROMO engineers provides guidance to determine step losses or non-operation across a variety of applications.

Posted in: White Papers, White Papers, Motors & Drives

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Optimizing Electronics for Medical Applications

Two years ago, in Medical Design Briefs, Derek Hunt offered some insight into the benefits of Complementary Metal-Oxide Semiconductor (CMOS) technology in the miniaturization of medical devices. CMOS has been around for decades and aside from the size benefits which will be discussed shortly, the technology also brings significant cost savings and performance improvements to the medical world. Readers who are currently engaged in the design of medical electronics already recognize this. It’s actually difficult to design such products today without incorporating CMOS devices. And because medical devices often contain many analog components, there remains one critical decision point designers must address and that is whether to design with standard off-the-shelf standard analog products or engage with a semiconductor company to produce a custom analog chip for the application.

Posted in: Features

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Making the Compliance Grade: Quantitative View on Compliance Management

Whether building enterprise-level solutions, using cloud-based solutions, or even building in-house solutions, the dynamic of automation is a key component in the compliance market. VERSE gauged the common challenges in compliance around Quality and Safety and compiled the results in this compliance grader white paper.

Posted in: White Papers, White Papers

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Relativistic Ion Tracks (RITRACKS)

Lyndon B. Johnson Space Center, Houston, Texas Once astronauts venture beyond Earth’s protective atmosphere, they are exposed to the high-energy charged particles of galactic cosmic rays (GCR) and solar particle events (SPE), and secondary protons and neutrons. GCR are composed of ions, the great majority of which are protons (≈87%) and helium nuclei (≈12%). The heavy ions of atomic number greater than 2 comprise only a small fraction of the charged particles in the GCR, but they contribute significantly to the radiation dose and dose equivalent over time. Because of their ionization patterns in biomolecules, cells and tissues are distinct from terrestrial radiation, the resulting biological effects are poorly understood, and the health risks of these radiations are subject to large uncertainties.

Posted in: Briefs

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Medical Oxygen Concentrator for Microgravity Operation

Only ambient air and DC energy are required to operate the system. John H. Glenn Research Center, Cleveland, Ohio Supplemental oxygen delivery systems are vital to provide a critical life support respiratory function. Whether they are used for patients suffering from lung diseases or other illnesses, or astronauts donning an oxygen mask during a toxic spill or fire on a spacecraft, lightweight and portable oxygen delivery systems are in high demand. A lightweight portable oxygen concentrator was developed that can produce 1 to 6 lpm of pulse oxygen in a noiseless system that can be worn on the user’s hip or in a shoulder sling.

Posted in: Briefs

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Lateral Displacement Device for Blood Cell Separation

This device has side microchannels where the particles are separated and collected. Lyndon B. Johnson Space Center, Houston, Texas Separation of particles based on size is one of the essential components in biochemical analysis, environmental assays, and industrial and biomedical applications. Filtration is one of the most frequently used techniques to separate particles. A mechanical filter can be used to remove, filter, or collect particles. This filtering and collection of particles can be used for sampling of particles, chemical detection, and/or biological cell analysis.

Posted in: Briefs

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