Health, Medicine, & Biotechnology

Rapid PCR Instrument Development

Today, there is great demand for next-generation polymerase chain reaction (PCR)-based diagnostics for the rapid analysis of patient samples and simultaneous detection of multiple diverse markers. Generally, PCR imaging systems limit testing to one, slow PCR protocol at a time. To complete multiple independent tests requires multiple runs over several hours or even days. The solution is a new, rapid, real-time PCR instrument with multiple, randomly accessible thermal blocks and easy-to-use software that provides researchers and clinicians with flexibility in workflow with rapid results in 20 minutes.

Posted in: White Papers

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Parallel Prototyping and the Engineer’s Dilemma

R&D Engineers face rapidly shrinking development cycles and rising competitive pressures. In the high-stakes practice of regulatory compliance, balancing development costs with speed, safety and performance are critical to a product’s success. This paper demonstrates how the parallel prototyping of two materials in a heating component contributes to the return on investment of a new product launch in the medical device industry. The study addresses the verification, validation, form and fit testing relative to the FDA approval process, as well as its execution within component design, product design and pilot production.

Posted in: White Papers, White Papers

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Molds for Medical Technology

The demand for productivity in the field of medical consumables is consistently growing at a rapid rate. The growth of the world’s population, expanding urbanization, aging societies, and increasing self-medication are contributing to this growing demand, despite manufacturers’ limited production space. Costs continue to rise, and manufacturers are increasingly looking at stack molds for their capability to double the output while reducing waste.

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The Truth about Parylene Coating & Medical Devices

Parylene is the generic name for members of a unique polymer series. Parylene conformal coatings represent a distinct family of organic polymeric coating materials that are polycrystalline and linear in nature, with innumerable commercial applications. Resilient, dielectric, and pinhole-free, parylenes are frequently selected for use with products subjected to ongoing conditions of duress that might otherwise diminish their performance.

Posted in: White Papers, White Papers, Coatings & Adhesives

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Intranasal Scopolamine — INSCOP

This drug, in intranasal form, is an effective treatment for motion sickness. Lyndon B. Johnson Space Center, Houston, Texas Space motion sickness (SMS) commonly experienced by astronauts during a space mission often requires treatment with medication. However, exposure to a microgravity environment results in a myriad of physiological changes that alter bioavailability. In particular, studies indicate that the bioavailability of oral scopolamine (SCOP) is decreased during spaceflight. Although altered gastrointestinal function, including delayed gastric emptying, appears to contribute to decreased bioavailability of oral medications, other factors typical of spaceflight may influence the pharmacokinetics of medications administered via a variety of other non-parenteral routes.

Posted in: Briefs

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Microbial Isolates from Research Activities as a Biological Resource

A collection of 1,530 individual isolates is used to evaluate the potential hazard of introducing sterilization-resistant microorganisms onto planetary spacecraft. NASA’s Jet Propulsion Laboratory, Pasadena, California International treaty requires spacecraft landing on planetary surfaces that may have water present, or may have supported life in the past, to adhere to strict guidelines governing the microbial contaminants that are incidentally present in, and on, spacecraft hardware introduced to those environments. Precautions to prevent microbial contamination of flight hardware are taken throughout assembly, test, and launch operations to minimize transferring biological contamination to the planet. Effectiveness of these precautions is assessed by conducting bioassays of spacecraft surfaces and assembly areas to estimate the number of microorganisms present. Microorganisms discovered are preserved as a living document and compendium for the mission. The organisms that are of greatest concern are those that are highly resistant to desiccation and spacecraft sterilization by dry heat.

Posted in: Briefs

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Chromatid Painting for Chromosomal Inversion Detection

Applications include clinical cytogenetics, biomedical research, and biodosimetry. Lyndon B. Johnson Space Center, Houston, Texas Chromosomal inversions, such as those occurring following exposure to ionizing radiation, are especially difficult to detect by current techniques. Therefore, their true frequency and importance have been underappreciated. Even the impressive technology of whole genome sequencing, which is becoming more readily and rapidly available, is useless for the detection of many chromosomal rearrangements within a chromosome. Likewise, stateof- the-art cytogenetic mBAND analysis of irradiated normal human tissue can only occasionally reveal radiationinduced inversions. A novel and innovative approach called differential Genomic Hybridization (dGH) or chromatid painting has been developed to further explore, expand, and capitalize on this new frontier of molecular cytogenetics.

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