Health, Medicine, & Biotechnology

Ultra-Sensitive Biosensor for Medical Diagnostics

This device may enable miniaturization and new point-of-care applications in doctors' offices. Researchers have created an ultrasensitive biosensor that could open up new opportunities for early detection of cancer and “personalized medicine” tailored to the specific biochemistry of individual patients. The device, which could be several hundred times more sensitive than other biosensors, combines the attributes of two distinctly different types of sensors, said Muhammad A. Alam, a Purdue Uni versity professor of electrical and computer engineering.

Posted in: Bio-Medical, Electronic Components, Sensors, Medical, Diagnostics, Briefs, MDB


Beat-to-Beat Blood Pressure Monitor

This invention is applicable to all segments of the blood pressure monitoring market, including ambulatory, home-based, and high-acuity monitoring. This device provides non-invasive beat-to-beat blood pressure measurements and can be worn over the upper arm for prolonged durations. Phase and waveform analyses are performed on filtered proximal and distal photoplethysmographic (PPG) waveforms obtained from the brachial artery. The phase analysis is used primarily for the computation of the mean arterial pressure, while the waveform analysis is used primarily to obtain the pulse pressure. Real-time compliance estimate is used to refine both the mean arterial and pulse pressures to provide the beat-to-beat blood pressure measurement.

Posted in: Bio-Medical, Medical, Patient Monitoring, Briefs, TSP, MDB


Loading, Release, Biodegradation, and Biocompatibility of a Nanovector Delivery System

This method enables targeted delivery of therapeutic or imaging agents within a patient by means of nested nanoparticles. A nanovector multistage system has been created to overcome or bypass sequential barriers within the human body, in order to deliver a therapeutic or imaging agent to a specific location. This innovation consists of a composition that includes two or more stages of particles, such that smaller, later-stage particles are contained in the larger, early-stage particles (see figure).

Posted in: Bio-Medical, Medical, Briefs


Hardy Bacterium Isolated From Two Geographically Distinct Spacecraft Assembly Cleanroom Facilities

A new species merits further study. Earlier studies have confirmed that a tenacious hardy bacterial population manages to persist and survive throughout a spacecraft assembly process. The widespread detection of these organisms underscores the challenges in eliminating them completely. Only comprehensive and repetitive microbial diversity studies of geographically distinct cleanroom facilities will bolster the understanding of planetary protection relevant microbes. Extensive characterizations of the physiological traits demonstrated by cleanroom microbes will aid NASA in gauging the forward contamination risk that hardy bacteria (such as Tersicoccus phoenicis) pose to spacecraft.

Posted in: Bio-Medical, Medical, Briefs


Bioabsorbable Material Textile for Improving In Vivo Device Design

Created by a carding and needle-punch process, this non-woven structure is designed to create three-dimensional environments for cell proliferation and function. A non-woven absorbable scaffold has been designed for implant devices in orthopedics, cardiology, and general surgery, as well as other in vivo applications. Where classic tissue engineering utilized non-woven textile structures as environments for cell growth, medical device developers are now going further to exploit the benefits of these bioabsorbable scaffolds for applications and surgical procedures right inside the body, as well as for cosmetic surgery, wound care, and more. BIOFELT combines the benefits of traditional 3D non-woven scaffold technology with advanced manufacturing techniques to deliver this transformative capability.

Posted in: Bio-Medical, Materials, Implants & Prosthetics, Medical, Orthopedics, Briefs, MDB


Rotary Sensing Technologies for Medical and Robotic Shaft Angle Sensing Applications

This technical brief provides an overview of existing types of rotary sensor technologies, and compares the strengths and weaknesses of each type for use as through-hole shaft angle sensing devices. Today’s sensor technologies for robotic and medical applications include many devices that have evolved from industrial applications. Because of this general migration, they are not ideally suited to the requirements in new robotic and medical products. Specifically, conventional contacting and non-contacting sensing solutions do not offer the customization, small package size(s), and environmental and durability requirements that are so necessary in these custom applications.

Posted in: Bio-Medical, Positioning Equipment, Sensors, Medical, Robotics, Briefs, MDB


Functional Electrical Stimulation Technique May Improve Neural Implants

Researchers improve the efficiency of devices that stimulate damaged nerves, reducing potential side effects. Electrical implants that shut down excessive activity in brain cells hold great potential for treating epilepsy and chronic pain. Likewise, devices that enhance neurons’ activity may help restore function to people with nerve damage.

Posted in: Bio-Medical, Electronic Components, Rehabilitation & Physical Therapy, Implants & Prosthetics, Medical, Briefs, MDB


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