Health, Medicine, & Biotechnology

Beat-to-Beat Blood Pressure Monitor

This invention is applicable to all segments of the blood pressure monitoring market, including ambulatory, home-based, and high-acuity monitoring. This device provides non-invasive beat-to-beat blood pressure measurements and can be worn over the upper arm for prolonged durations. Phase and waveform analyses are performed on filtered proximal and distal photoplethysmographic (PPG) waveforms obtained from the brachial artery. The phase analysis is used primarily for the computation of the mean arterial pressure, while the waveform analysis is used primarily to obtain the pulse pressure. Real-time compliance estimate is used to refine both the mean arterial and pulse pressures to provide the beat-to-beat blood pressure measurement.

Posted in: Bio-Medical, Briefs, TSP, Briefs, TSP, Patient Monitoring


Loading, Release, Biodegradation, and Biocompatibility of a Nanovector Delivery System

This method enables targeted delivery of therapeutic or imaging agents within a patient by means of nested nanoparticles. A nanovector multistage system has been created to overcome or bypass sequential barriers within the human body, in order to deliver a therapeutic or imaging agent to a specific location. This innovation consists of a composition that includes two or more stages of particles, such that smaller, later-stage particles are contained in the larger, early-stage particles (see figure).

Posted in: Bio-Medical, Briefs


Hardy Bacterium Isolated From Two Geographically Distinct Spacecraft Assembly Cleanroom Facilities

A new species merits further study. Earlier studies have confirmed that a tenacious hardy bacterial population manages to persist and survive throughout a spacecraft assembly process. The widespread detection of these organisms underscores the challenges in eliminating them completely. Only comprehensive and repetitive microbial diversity studies of geographically distinct cleanroom facilities will bolster the understanding of planetary protection relevant microbes. Extensive characterizations of the physiological traits demonstrated by cleanroom microbes will aid NASA in gauging the forward contamination risk that hardy bacteria (such as Tersicoccus phoenicis) pose to spacecraft.

Posted in: Bio-Medical, Briefs


Bioabsorbable Material Textile for Improving In Vivo Device Design

Created by a carding and needle-punch process, this non-woven structure is designed to create three-dimensional environments for cell proliferation and function. A non-woven absorbable scaffold has been designed for implant devices in orthopedics, cardiology, and general surgery, as well as other in vivo applications. Where classic tissue engineering utilized non-woven textile structures as environments for cell growth, medical device developers are now going further to exploit the benefits of these bioabsorbable scaffolds for applications and surgical procedures right inside the body, as well as for cosmetic surgery, wound care, and more. BIOFELT combines the benefits of traditional 3D non-woven scaffold technology with advanced manufacturing techniques to deliver this transformative capability.

Posted in: Bio-Medical, Briefs, Briefs, Implants & Prosthetics, Orthopedics


Rotary Sensing Technologies for Medical and Robotic Shaft Angle Sensing Applications

This technical brief provides an overview of existing types of rotary sensor technologies, and compares the strengths and weaknesses of each type for use as through-hole shaft angle sensing devices. Today’s sensor technologies for robotic and medical applications include many devices that have evolved from industrial applications. Because of this general migration, they are not ideally suited to the requirements in new robotic and medical products. Specifically, conventional contacting and non-contacting sensing solutions do not offer the customization, small package size(s), and environmental and durability requirements that are so necessary in these custom applications.

Posted in: Bio-Medical, Briefs, Briefs, Positioning Equipment, Robotics, Sensors


Functional Electrical Stimulation Technique May Improve Neural Implants

Researchers improve the efficiency of devices that stimulate damaged nerves, reducing potential side effects. Electrical implants that shut down excessive activity in brain cells hold great potential for treating epilepsy and chronic pain. Likewise, devices that enhance neurons’ activity may help restore function to people with nerve damage.

Posted in: Bio-Medical, Briefs, Briefs, Electronic Components, Implants & Prosthetics, Rehabilitation & Physical Therapy


Monitoring Location and Angular Orientation of a Pill

System is part of targeted drug delivery. A mobile pill transmitter system moves through, or adjacent to, one or more organs in an animal or human body, while transmitting signals from its present location and/or present angular orientation. The system also provides signals from which the present roll angle of the pill, about a selected axis, can be determined. When the location coordinates angular orientation and the roll angle of the pill are within selected ranges, an aperture on the pill container releases a selected chemical into, or onto, the body. Optionally, the pill, as it moves, provides a sequence of visually perceptible images. The times for image formation may correspond to times at which the pill transmitter system location or image satisfies one of at least four criteria.

Posted in: Bio-Medical, Briefs, TSP


White Papers

Remediation and Prevention of Moisture in Electronics
Sponsored by multisorb technologies
9 Questions to Ask when Specifying a Slewing Ring Bearing
Sponsored by Kaydon
Introduction to Hypervisor Technology
Sponsored by Curtiss-Wright Controls Embedded Computing
Today’s Advanced Hose and Hydraulic Systems
Sponsored by Gates
CFD for Mechanical Design Engineers - “A Paradigm Shift for Better Design”
Sponsored by Mentor Graphics
One Component Epoxies: Versatility and Convenience
Sponsored by master bond

White Papers Sponsored By: