Health, Medicine, & Biotechnology

Fluorescence-Activated Cell Sorting of Live Versus Dead Bacterial Cells and Spores

Commercial applications include hospital operating room cleanliness validation assays, pharmaceutical development, and semiconductor development. This innovation is a coupled fluorescence-activated cell sorting (FACS) and fluorescent staining technology for purifying (removing cells from sampling matrices), separating (based on size, density, morphology, and live versus dead), and concentrating cells (spores, prokaryotic, eukaryotic) from an environmental sample.

Posted in: Bio-Medical, Medical, Briefs, TSP


Nonhazardous Urine Pretreatment Method

This method can be used as a means for safe urine storage on ships, planes, and recreational vehicles, or in conjunction with portable restrooms. A method combines solid phase acidification with two non-toxic biocides to prevent ammonia volatilization and microbial proliferation. The safe, nonoxidizing biocide combination consists of a quaternary amine and a food preservative. This combination has exhibited excellent stabilization of both acidified and unacidified urine.

Posted in: Bio-Medical, Medical, Briefs


Method and Apparatus for Automated Isolation of Nucleic Acids from Small Cell Samples

Advantages include reduced or eliminated use of toxic reagents and operator-independent extraction. RNA isolation is a ubiquitous need, driven by current emphasis on microarrays and miniaturization. With commercial systems requiring 100,000 to 1,000,000 cells for successful isolation, there is a growing need for a small-footprint, easy-to-use device that can harvest nucleic acids from much smaller cell samples (1,000 to 10,000 cells). The process of extraction of RNA from cell cultures is a complex, multi-step one, and requires timed, asynchronous operations with multiple reagents/buffers. An added complexity is the fragility of RNA (subject to degradation) and its reactivity to surface.

Posted in: Bio-Medical, Drug Delivery & Dispensing, Automation & Controls, Biosensors, Medical, Briefs, MDB


Flexible Sensors Offer View into Epileptic Seizures

Brain activity can be monitored and sampled using minimal amount of wires and electrodes and improving implantable devices. Tapping into the human brain to understand its functions in daily life — as well as its malfunctions in illness — has long been a challenge for researchers. Mapping brain activity requires unwieldy, invasive arrays of electrodes and sensors that can damage tissue while only reading activity in a limited area. A team of researchers at the Polytechnic Institute of New York University (NYUPoly) partnering with researchers from the University of Pennsylvania and the University of Illinois at Urbana-Champaign, have devised a streamlined, minimally invasive brain interface that may yield new insights into the causes of brain diseases like epilepsy and could potentially lead to new implantable neuroprosthetic and diagnostic devices.

Posted in: Bio-Medical, Imaging & Diagnostics, Monitoring & Testing, Electronics, Implants & Prosthetics, Biosensors, Treatment Devices, Medical, Briefs, MDB


Biosensor May Improve Disease Detection

A new biosensor could rapidly and accurately detect early stage disease in very low concentrations. A quick, inexpensive and highly sensitive test that identifies disease markers or other molecules in low-concentration solutions could be the result of a Cornell-developed nanomechanical biosensor, which could potentially help with early stage disease detection.

Posted in: Bio-Medical, Imaging & Diagnostics, Electronics, Materials / Adhesives / Coatings, Biosensors, Medical, Briefs, MDB


Fingertip-Sized Microscope to Study the Brain and its Diseases

A tiny portable microscope can be used in the lab or in the field for biological research and potentially for medical screening of diseases. A readily portable miniature microscope weighing less than 2 grams and tiny enough to balance on your fingertip has been developed. The scope is designed to see fluorescent markers, such as dyes, commonly used by medical and biological researchers studying the brains of mice.

Posted in: Bio-Medical, Imaging & Diagnostics, Optics/Photonics, Inspection Equipment, Medical, Briefs, MDB


Silk Microneedles Deliver Controlled-Release Drugs Painlessly

Tiny needles deliver precise amounts of drugs over time without need for refrigeration. Bioengineers have developed a new silk-based microneedle system able to deliver precise amounts of drugs over time and without need for refrigeration. The tiny needles can be fabricated under normal temperature and pressure and from water, so they can be loaded with sensitive biochemical compounds and maintain their activity prior to use. They are also biodegradable and biocompatible.

Posted in: Bio-Medical, Drug Delivery & Dispensing, Treatment Devices, Materials, Medical, Drug Delivery & Fluid Handling, Briefs, MDB