Medical

Biosensor May Improve Disease Detection

A new biosensor could rapidly and accurately detect early stage disease in very low concentrations. A quick, inexpensive and highly sensitive test that identifies disease markers or other molecules in low-concentration solutions could be the result of a Cornell-developed nanomechanical biosensor, which could potentially help with early stage disease detection.

Posted in: Bio-Medical, Imaging & Diagnostics, Electronics, Materials / Adhesives / Coatings, Biosensors, Medical, Briefs, MDB

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Fingertip-Sized Microscope to Study the Brain and its Diseases

A tiny portable microscope can be used in the lab or in the field for biological research and potentially for medical screening of diseases. A readily portable miniature microscope weighing less than 2 grams and tiny enough to balance on your fingertip has been developed. The scope is designed to see fluorescent markers, such as dyes, commonly used by medical and biological researchers studying the brains of mice.

Posted in: Bio-Medical, Imaging & Diagnostics, Optics/Photonics, Inspection Equipment, Medical, Briefs, MDB

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Silk Microneedles Deliver Controlled-Release Drugs Painlessly

Tiny needles deliver precise amounts of drugs over time without need for refrigeration. Bioengineers have developed a new silk-based microneedle system able to deliver precise amounts of drugs over time and without need for refrigeration. The tiny needles can be fabricated under normal temperature and pressure and from water, so they can be loaded with sensitive biochemical compounds and maintain their activity prior to use. They are also biodegradable and biocompatible.

Posted in: Bio-Medical, Drug Delivery & Dispensing, Treatment Devices, Materials, Medical, Drug Delivery & Fluid Handling, Briefs, MDB

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Beat-to-Beat Blood Pressure Monitor

This invention is applicable to all segments of the blood pressure monitoring market, including ambulatory, home-based, and high-acuity monitoring. This device provides non-invasive beat-to-beat blood pressure measurements and can be worn over the upper arm for prolonged durations. Phase and waveform analyses are performed on filtered proximal and distal photoplethysmographic (PPG) waveforms obtained from the brachial artery. The phase analysis is used primarily for the computation of the mean arterial pressure, while the waveform analysis is used primarily to obtain the pulse pressure. Realtime compliance estimate is used to refine both the mean arterial and pulse pressures to provide the beat-to-beat blood pressure measurement.

Posted in: Bio-Medical, Physical Sciences, Test & Measurement, Medical, Patient Monitoring, Measuring Instruments, Monitoring, Briefs

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Developing Physiologic Models for Emergency Medical Procedures Under Microgravity

Several technological enhancements have been made to METI’s commercial Emergency Care Simulator (ECS) with regard to how microgravity affects human physiology. The ECS uses both a software only lung simulation, and an integrated mannequin lung that uses a physical lung bag for creating chest excursions, and a digital simulation of lung mechanics and gas exchange. METI’s patient simulators incorporate models of human physiology that simulate lung and chest wall mechanics, as well as pulmonary gas exchange.

Posted in: Bio-Medical, Software, Medical, Patient Monitoring, Diagnostics, Briefs, TSP

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Improving Balance Function Using Low Levels of Electrical Stimulation of the Balance Organs

A device based on this technology may be used as a miniature patch worn by people with disabilities to improve posture and locomotion, and to enhance adaptability or skill acquisition. Crewmembers returning from long duration space flight face significant challenges due to the microgravity induced inappropriate adaptations in balance/sensorimotor function. The Neuroscience Laboratory at JSC is developing a method based on stochastic resonance to enhance the brain’s ability to detect signals from the balance organs of the inner ear and use them for rapid improvement in balance skill, especially when combined with balance training exercises. This method involves a stimulus delivery system that is wearable/ portable providing imperceptible electrical stimulation to the balance organs of the human body.

Posted in: Bio-Medical, Sensors, Rehabilitation & Physical Therapy, Medical, Briefs

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Hands-Free Transcranial Color Doppler Probe

These probes enable full use of TCD technology for neurological diagnostics. Current transcranial color Doppler (TCD) transducer probes are bulky and difficult to move in tiny increments to search and optimize TCD signals. This invention provides miniature motions of a TCD transducer probe to optimize TCD signals.

Posted in: Bio-Medical, Visualization Software, Imaging, Surgical Robotics/Instruments, Medical, Patient Monitoring, Diagnostics, Briefs

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