Health, Medicine, & Biotechnology

Magnetic Plungerless Injection System

This system provides an enclosed and completely sealed system that preserves sterility, and both injects and extracts liquid or gas substances. The Magnetic Plungerless Injection System (MPIS) was invented to enhance the therapeutic value and market availability of parenterally delivered pharmaceuticals and vaccines. The MPIS is a mechanical arrangement of a proprietary single-dosage cartridge and a magnetic actuator, and is a combination of the storage and the injector/extractor (syringe). The design answers many questions raised by the existing hypodermic syringe.

Posted in: Bio-Medical, Briefs, Briefs, Drug Delivery & Fluid Handling

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Exact Dose Dispensing Closure for Semi-Solids

This device replaces a conventional tube cap and enables a user to dispense an exact dose. A novel closure technology now makes it possible to consistently squeeze an exact dose of semi-solids from a tube by means of a 180-degree rotating closure. It has potential uses in pharmaceutical transdermal and oral applications, as well as glue dispensing, semi-solid food dispensing, and paint dispensing. Other potential applications are exact dose dispensing of prescription toothpaste, food condiments, or cosmetic products such as sunscreen creams and skin care formulations.

Posted in: Bio-Medical, Briefs, Briefs, Drug Delivery & Fluid Handling

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Graphite Non-Wovens as Functional Layers in Diagnostic Test Kits

Blood-handling diagnostic test strips can be used for diabetes testing and monitoring, and testing for other diseases. The separation of serum or plasma from whole blood is of overriding importance in clinical chemistry. In particular, many diagnostic detection reactions of blood components proceed without impairment only after the red blood corpuscles have been separated off. This particularly applies to color reactions that are evaluated either by reflectometry or visually, or also electrochemically.

Posted in: Briefs, Briefs, Coatings & Adhesives, Patient Monitoring

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Modular Electronic Air Sterilization Technology

This germicidal irradiation system eliminates airborne bacteria, molds, and viruses in one pass. Ultraviolet germicidal irradiation (UVGI) technologies are being used as infection control devices, primarily in healthcare facilities. No standard exists, but the dose of UV and the airflow are critical to ensuring all contaminated air is treated. The UVGI process is mainly influenced by the microorganism population, the irradiation intensity, and the intimate exposure time to the lamps. This new technology enables the system to increase the intensity field or to improve the inactivation process, without adding more energy or increasing the output efficiency of the lamps.

Posted in: Bio-Medical, Briefs, Briefs, Electronics

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Quantifying Therapeutic and Diagnostic Efficacy in 2D Microvascular Images

VESGEN is a newly automated, userinteractive program that maps and quantifies the effects of vascular therapeutics and regulators on microvascular form and function. VESGEN analyzes two-dimensional, black and white vascular images by measuring important vessel morphology parameters. This software guides the user through each required step of the analysis process via a concise graphical user interface (GUI). There are control options ranging from “one-click” analysis given a primary output, to step-by-step control over each image and algorithm used in an analysis. An option is provided to select a vascular tissue type, which determines the general collections of algorithms, intermediate images, and output images and measurements that will be produced. The UI automatically restructures itself to provide customized user controls for studying the requested type of tissue.

Posted in: Briefs, Briefs, Diagnostics

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Microwave Sterilization and Depyrogenation System

Lightweight and portable systems can be deployed to provide medical-grade water. A fully functional, microgravity-compatible microwave sterilization and depyrogenation system (MSDS) prototype was developed that is capable of producing medical-grade water (MGW) without expendable supplies, using NASA potable water that currently is available aboard the International Space Station (ISS) and will be available for Lunar and planetary missions in the future. The microwavebased, continuous MSDS efficiently couples microwaves to a single-phase, pressurized, flowing water stream that is rapidly heated above 150 ºC. Under these conditions, water is rapidly sterilized. Endotoxins, significant biological toxins that originate from the cell walls of gram-negative bacteria and which represent another defining MGW requirement, are also deactivated (i.e., depyrogenated) albeit more slowly, with such deactivation representing a more difficult challenge than sterilization.

Posted in: Bio-Medical, Briefs, TSP, Briefs, TSP, Patient Monitoring

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Reliability and Validity of a Prototype Fluid Intake Monitor

Fluid intake monitors are designed to ensure that soldiers consume recommended amounts of water.Maintaining adequate hydration is an important part of maintaining health, especially under extreme operational and environmental conditions where medical assistance might not be readily available. One approach to measuring the amount of fluid consumed is through the use of Fluid Intake Monitor (FIM) technologies to monitor fluid consumption. These devices can be used to ensure that warfighters consume recommended/ appropriate amounts of water, and to tailor logistical support to actual water needs, as water is expensive to transport.

Posted in: Bio-Medical, Briefs, TSP, Briefs, TSP, Patient Monitoring

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