Medical

Three-Dimensional Optical Coherence Tomography

Advantages over prior OCT systems include less bulk and greater speed. Three-dimensional (3D) optical coherence tomography (OCT) is an advanced method of noninvasive infrared imaging of tissues in depth. Heretofore, commercial OCT systems for 3D imaging have been designed principally for external ophthalmological examination. As explained below, such systems have been based on a one- dimensional OCT principle, and in the operation of such a system, 3D imaging is accomplished partly by means of a combination of electronic scanning along the optical (Z) axis and mechanical scanning along the two axes (X and Y) orthogonal to the optical axis.

Posted in: Bio-Medical, Medical, Diagnostics, Briefs, TSP, MDB

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Isolation of Precursor Cells From Waste Solid Fat Tissue

A process for isolating tissue-specific progenitor cells exploits solid fat tissue obtained as waste from such elective surgical procedures as abdominoplasties (“tummy tucks”) and breast reductions. Until now, a painful and risky process of aspiration of bone marrow has been used to obtain a limited number of tissue-specific progenitor cells.

Posted in: Bio-Medical, Medical, Patient Monitoring, Briefs, TSP, MDB

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Benchtop Antigen Detection Technique Using Nanofiltration and Fluorescent Dyes

This technique can help to monitor the quality of water by testing for contamination at restaurants, water treatment plants, and food processing plants. The designed benchtop technique is primed to detect bacteria and viruses from antigenic surface marker proteins in solutions, initially water. This inclusive bio-immunoassay uniquely combines nanofiltration and near infrared (NIR) dyes conjugated to antibodies to isolate and distinguish microbial antigens, using laser excitation and spectrometric analysis. The project goals include detecting microorganisms aboard the International Space Station, space shuttle, Crew Exploration Vehicle (CEV), and human habitats on future Moon and Mars missions, ensuring astronaut safety. The technique is intended to improve and advance water contamination testing both commercially and environmentally as well. Lastly, this streamlined technique poses to greatly simplify and expedite testing of pathogens in complex matrices, such as blood, in hospital and laboratory clinics.

Posted in: Bio-Medical, Medical, Patient Monitoring, Briefs, TSP, MDB

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Wireless, Handheld Electronic Medical Record Application

Healthcare providers can view, update, and share patient information from a handheld device. PocketChart™, available in numerous medical specialty editions, is a wireless, handheld electronic medical record application that will help physicians increase productivity, reduce transcription costs, and increase revenue through improved code levels. PocketChart enables a PocketPC to synchronize with a desktop computer, allowing healthcare providers to continuously update, view, exchange, and print patient information. It is designed for use at point-of-care in a variety of clinical settings including hospitals, homes, and extended-care facilities.

Posted in: Bio-Medical, Patient Data Management, Electronics & Computers, Electronics, Software, Medical, Briefs, MDB

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Identification of Bacteria and Determination of Biological Indicators

Identifying mechanisms of micro-organisms can prevent forward contamination in space missions and can help in developing new antibiotics and amino acids. The ultimate goal of planetary protection research is to develop superior strategies for inactivating resistance-bearing micro-organisms like Rummelibacillus stabekisii. By first identifying the particular physiologic pathway and/or structural component of the cell/spore that affords it such elevated tolerance, eradication regimes can then be designed to target these resistance-conferring moieties without jeopardizing the structural integrity of spacecraft hardware. Furthermore, hospitals and government agencies frequently use biological indicators to ensure the efficacy of a wide range of sterilization processes. The spores of Rummelibacillus stabekisii, which are far more resistant to many of such perturbations, could likely serve as a more significant biological indicator for potential survival than those being used currently.

Posted in: Bio-Medical, Medical, Patient Monitoring, Briefs, MDB

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Further Development of Scaffolds for Regeneration of Nerves

Scale-up toward clinically significant dimensions has been partially completed. Progress has been made in continuing research on scaffolds for the guided growth of nerves to replace damaged ones. The scaffolds contain pores that are approximately cylindrical and parallel, with nearly uniform widths ranging from tens to hundreds of microns. At the earlier stage of development, experimental scaffolds had been made from agarose hydrogel. Such a scaffold was made in a multistep process in which poly(methyl methacrylate) [PMMA] fibers were used as templates for the pores. The process included placement of a bundle of the PMMA fibers in a tube, filling the interstices in the tube with a hot agarose solution, cooling to turn the solution into a gel, and then immersion in acetone to dissolve the PMMA fibers. The scaffolds were typically limited to about 25 pores per scaffold, square cross sections of no more than about 1.5 by 1.5 mm, and lengths of no more than about 2 mm.

Posted in: Bio-Medical, Manufacturing & Prototyping, Medical, Briefs, MDB

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Chemically Assisted Photocatalytic Oxidation System

The chemically assisted photocatalytic oxidation system (CAPOS) has been proposed for destroying micro-organisms and organic chemicals that may be suspended in the air or present on surfaces of an air-handling system that ventilates an indoor environment. The CAPOS would comprise an upstream and a downstream stage that would implement a tandem combination of two partly redundant treatments. In the upstream stage, the air stream and, optionally, surfaces of the air-handling system would be treated with ozone, which would be generated from oxygen in the air by means of an electrical discharge or ultraviolet light. In the second stage, the air laden with ozone and oxidation products from the first stage would be made to flow in contact with a silica-titania photocatalyst exposed to ultraviolet light in the presence of water vapor. Hydroxyl radicals generated by the photocatalytic action would react with both carbon-containing chemicals and microorganisms to eventually produce water and carbon dioxide, and ozone from the first stage would be photocatalytically degraded to O2. The net products of the two-stage treatment would be H2O, CO2, and O2.

Posted in: Bio-Medical, Medical, Patient Monitoring, Briefs, MDB

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