Health, Medicine, & Biotechnology

Quantifying Therapeutic and Diagnostic Efficacy in 2D Microvascular Images

VESGEN is a newly automated, userinteractive program that maps and quantifies the effects of vascular therapeutics and regulators on microvascular form and function. VESGEN analyzes two-dimensional, black and white vascular images by measuring important vessel morphology parameters. This software guides the user through each required step of the analysis process via a concise graphical user interface (GUI). There are control options ranging from “one-click” analysis given a primary output, to step-by-step control over each image and algorithm used in an analysis. An option is provided to select a vascular tissue type, which determines the general collections of algorithms, intermediate images, and output images and measurements that will be produced. The UI automatically restructures itself to provide customized user controls for studying the requested type of tissue.

Posted in: Briefs, Briefs, Diagnostics

Read More >>

Microwave Sterilization and Depyrogenation System

Lightweight and portable systems can be deployed to provide medical-grade water. A fully functional, microgravity-compatible microwave sterilization and depyrogenation system (MSDS) prototype was developed that is capable of producing medical-grade water (MGW) without expendable supplies, using NASA potable water that currently is available aboard the International Space Station (ISS) and will be available for Lunar and planetary missions in the future. The microwavebased, continuous MSDS efficiently couples microwaves to a single-phase, pressurized, flowing water stream that is rapidly heated above 150 ºC. Under these conditions, water is rapidly sterilized. Endotoxins, significant biological toxins that originate from the cell walls of gram-negative bacteria and which represent another defining MGW requirement, are also deactivated (i.e., depyrogenated) albeit more slowly, with such deactivation representing a more difficult challenge than sterilization.

Posted in: Bio-Medical, Briefs, TSP, Briefs, TSP, Patient Monitoring

Read More >>

Reliability and Validity of a Prototype Fluid Intake Monitor

Fluid intake monitors are designed to ensure that soldiers consume recommended amounts of water.Maintaining adequate hydration is an important part of maintaining health, especially under extreme operational and environmental conditions where medical assistance might not be readily available. One approach to measuring the amount of fluid consumed is through the use of Fluid Intake Monitor (FIM) technologies to monitor fluid consumption. These devices can be used to ensure that warfighters consume recommended/ appropriate amounts of water, and to tailor logistical support to actual water needs, as water is expensive to transport.

Posted in: Bio-Medical, Briefs, TSP, Briefs, TSP, Patient Monitoring

Read More >>

Computer-Assisted Laser Treatment Using Real-Time Retinal Tracking

This computerized system accurately guides laser shots to diseased retinal areas. Diabetic retinopathy resulting from long-term diabetes mellitus is one of the common diseases that leads to choroidal neovascularization (CNV), a leading cause of blindness. Among the currently available treatment methods, a laser can be used to photocoagulate the diseased areas. Several thousand laser shots are usually required during such treatment. Special care must be taken to avoid hitting the blood vessel tree, the macula, the optic disk, and the region among them. For a single eye, this procedure requires up to several hours that are usually divided over many treatment sessions. Consequently, the development of an accurate laser treatment guidance system to treat the whole retina in one session would improve the effectiveness of such procedures.

Posted in: Bio-Medical, Briefs, TSP, Briefs, TSP, Lasers & Laser Systems, Photonics

Read More >>

Medical Information Network Decision Support System

A standardized platform stores and fuses medical data, while providing probabilistic diagnostic and treatment decisions. In order to facilitate a more rapid and systematic transfer of new medical knowledge and capabilities into mainstream clinical practice, a new Medical Information Network Decision Support (MINDS) system was developed. This system is intended to be a platform for storing and fusing medical data in a standardized way, and for providing probabilistic diagnostic and treatment decisions to assist doctors and medical researchers in understanding and treating disease.

Posted in: Patient Data Management, Bio-Medical, Briefs, TSP, Briefs, TSP

Read More >>

Quantifying Therapeutic and Diagnostic Efficacy in 2D Microvascular Images

VESGEN is a newly automated, user- interactive program that maps and quantifies the effects of vascular therapeutics and regulators on microvascular form and function. VESGEN analyzes two- dimensional, black and white vascular images by measuring important vessel morphology parameters. This software guides the user through each required step of the analysis process via a concise graphical user interface (GUI). There are control options ranging from “one-click” analysis given a primary output, to step-by-step control over each image and algorithm used in an analysis. An option is provided to select a vascular tissue type, which determines the general collections of algorithms, intermediate images, and output images and measurements that will be produced. The UI automatically restructures itself to provide customized user controls for studying the requested type of tissue.

Posted in: Bio-Medical, Briefs, TSP, Briefs, TSP, Diagnostics

Read More >>

Micro-Organ Devices

Effects of drugs can be tested realistically, without experimentation on animals. Micro-organ devices (MODs) are being developed to satisfy an emerging need for small, lightweight, reproducible, biological-experimentation apparatuses that are amenable to automated operation and that impose minimal demands for resources (principally, power and fluids). MODs are intended to overcome major disadvantages of conventional in vitro and conventional in vivo experimentation for purposes of investigating effects of medicines, toxins, and possibly other foreign substances.

Posted in: Bio-Medical, Briefs, Briefs, Drug Delivery & Fluid Handling, Patient Monitoring

Read More >>