Health, Medicine, & Biotechnology

Software for Image Contrast Enhancement

This technique provides detail and edge contrast enhancement, latitude reduction, and noise reduction when applied to digitizers for X-ray imaging.

Whenever images are acquired with a large dynamic range, a problem arises in reproducing these images on a medium (i.e. CRT, paper). There are the restrictions of the recording apparatus (number of reproducible intensity levels, color gamut, and color resolution) as well as environmental factors (flare, light level).

Posted in: Briefs, MDB, Briefs, Bio-Medical, Diagnostics, Medical, Software, Computer software / hardware, Computer software and hardware, Imaging, Imaging and visualization, Computer software / hardware, Computer software and hardware, Imaging, Imaging and visualization, Displays, Displays
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Highly Sensitive Micro Fluorescence Detector for Bioanalytical Devices

This development represents an advancement in the field of portable microfluidic analysis systems, or lab-on-a-chip devices.

An advanced micro fluorescence detector (microFD) uses a hydrogenated amorphous silicon (a-Si:H) photodiode for high sensitivity biochemical analyses in micro-capillary electrophoresis (microCE) applications, representing an advancement in the field of portable microfluidic analysis systems, or lab-on-a-chip devices. The detector is highly sensitive to the emission wavelengths of commonly used fluorescent dyes, and in an integrated configuration using a Vertical Cavity Surface Emitting Laser (VCSEL) diode, proves efficacious for heavily multiplexed microfluidic biochemical analyses. This design can be fabricated and integrated at a low cost, making it ideal for the production of portable bioanalyzers that handle minute quantities of fluids (picoliters to nanoliters), as well as emerging large-scale integrated microfluidic technologies.

Posted in: Briefs, MDB, Briefs, Bio-Medical, Diagnostics, Medical, Patient Monitoring, Lasers, Sensors and actuators, Lasers, Sensors and actuators, Diagnosis, Fluids and secretions, Medical equipment and supplies
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Medical Tube Securing Device

A novel device secures medical tubes and catheters intubated within a patient.

The Burn Center, located in the Brooke Army Medical Center, receives approximately 300 burn patients each year. Often, these patients have problems breathing on their own due to scorched esophagi, damaged airways due to smoke inhalation, or organ failures.

Posted in: Briefs, MDB, Briefs, Mechanical Components, Bio-Medical, Medical, Life support systems, Medical equipment and supplies, Mountings, Hoses, Injuries
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CMOS-Based X-Ray Panel Focuses on Low-Dose Applications

The technology enables real-time imaging for cardiac, vascular, and orthopedic procedures.

In all domains of medical and scientific X-ray imaging, the replacement of film and analog video imaging techniques with a fully digital workflow is underway. The Xineos X-ray panel X-ray CMOS technology delivers three times more sensitivity and five times more signal-to-noise performance than other standard technologies, enabling radiologists and practitioners to reduce patient dose in dynamic X-ray imaging modalities such as fluoroscopy and computed tomography.

Posted in: Briefs, MDB, Briefs, Bio-Medical, Diagnostics, Medical, Imaging, Imaging and visualization, Integrated circuits, Imaging, Imaging and visualization, Integrated circuits, Diagnosis, Medical equipment and supplies
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Hydrofocusing Bioreactor Produces Anti-Cancer Alkaloids

Enhancement of production may be attributable to favorable aggregation of cells.

A methodology for growing three-dimensional plant tissue models in a hydrodynamic focusing bioreactor (HFB) has been developed. The methodology is expected to be widely applicable, both on Earth and in outer space, as a means of growing plant cells and aggregates thereof under controlled conditions for diverse purposes, including research on effects of gravitation and other environmental factors upon plant growth and utilization of plant tissue cultures to produce drugs in quantities greater and at costs lower than those of conventional methodologies

Posted in: Briefs, TSP, Bio-Medical, Medical, Biological sciences
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A Miniaturized Video System for Monitoring Drosophila Behavior

This method allows monitoring the movement of many fruit flies in space simultaneously.

Long-term spaceflight may induce a variety of harmful effects in astronauts, resulting in altered motor and cognitive behavior. The stresses experienced by humans in space — most significantly weightlessness (microgravity) and cosmic radiation — are difficult to accurately simulate on Earth. In fact, prolonged and concomitant exposure to microgravity and cosmic radiation can only be studied in space.

Posted in: Briefs, TSP, Bio-Medical, Medical, Human factors, Mental processes, Radiation
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Biomedical Textile Material Selection and Performance Considerations in Device Design

Biocompatible materials are increasingly being refined for incorporation in therapeutic applications.

Biomedical textile structures incorporate a wide array of biocompatible materials, including advanced polymers and metals in a range of sizes and thicknesses with varying material characteristics and performance properties. Promising substrates, now in development, add to the diversity of biomedical textile structure options. This versatility puts device designers within reach of developing highly complex, ultra-sophisticated components that can be used in a number of therapeutic applications, including orthopedics, cardiovascular, tissue engineering, neurology, and general surgery.

Posted in: Briefs, MDB, Briefs, Coatings & Adhesives, Materials, Bio-Medical, Implants & Prosthetics, Medical, Medical equipment and supplies, Biomaterials, Materials identification, Metals, Polymers, Textiles
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SCAFTEX® Non-Woven Bio-Textile for Implantable Devices

With the ability to encourage cellular in-growth, this material may become increasingly important to orthopedic reconstruction.

Classic tissue engineering utilizes absorbable non-woven biomedical textiles from a variety of fibers to aid in cell growth and proliferation, and medical device companies rely on these materials for implantable devices that must degrade over time. Non-woven bio-textiles such as SCAFTEX® and others have become the material of choice for many tissue engineering and regenerative medicine applications, and with superior surface area, high void volume, and excellent permeability, they are now also increasingly used in a wide variety of restorative applications ranging from orthopedic reconstruction and wound management to cosmetic surgery.

Posted in: Briefs, MDB, Briefs, Coatings & Adhesives, Materials, Bio-Medical, Implants & Prosthetics, Medical, Prostheses and implants, Suppliers, Biomaterials, Textiles
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Stereotactic System for Localizing Intracranial Targets

This technology helps guide instruments including biopsy forceps, deep brain electrodes, and endoscopes.

The CRW® stereotactic system, first released in 1988, was recently updated to focus on decreasing the steps to assemble the system while maintaining ±0.5 mm accuracy. This multi-purpose system is useful for localizing intracranial targets for precisely directing instruments. It is indicated for use in neurological procedures that require precise target localization such as craniotomies, biopsies, and functional neurosurgery. Typical instruments guided by CRW systems include biopsy forceps, radiofrequency lesioning electrodes, deep brain electrodes, recording and stimulating electrodes, hematoma evacuators, and endoscopes.

Posted in: Briefs, MDB, Briefs, Mechanical Components, Bio-Medical, Diagnostics, Medical, Electronic control systems, Electronic control systems, Medical equipment and supplies, Nervous system, Surgical procedures
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Microwave Tissue Soldering for Immediate Wound Closure

Wounds can be closed rapidly, without staples, sutures, or tapes.

A novel approach for the immediate sealing of traumatic wounds is under development. A portable microwave generator and handheld antenna are used to seal wounds, binding the edges of the wound together using a biodegradable protein sealant or “solder.” This method could be used for repairing wounds in emergency settings, by restoring the wound surface to its original strength within minutes. This technique could also be utilized for surgical purposes involving solid visceral organs (i.e., liver, spleen, and kidney) that currently do not respond well to ordinary surgical procedures.

Posted in: Briefs, MDB, Briefs, Bio-Medical, Medical, Lasers & Laser Systems, Photonics, Antennas, Antennas, Medical equipment and supplies, Adhesives and sealants, Injuries
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