Medical

Portable Unit for Metabolic Analysis

Respiratory signals can be temporally resolved within respiratory cycles. The Portable Unit for Metabolic Analysis (PUMA) is an instrument that measures several quantities indicative of human metabolic function. Specifically, this instrument makes time-resolved measurements of temperature, pressure, flow, and the partial pressures of oxygen and carbon dioxide in breath during both inhalation and exhalation.

Posted in: Medical, Briefs

Read More >>

Advanced Resistive Exercise Device

A number of different exercises can be performed on one machine. The advanced resistive exercise device (ARED), now at the prototype stage of development, is a versatile machine that can be used to perform different customized exercises for which, heretofore, it has been necessary to use different machines. Conceived as a means of helping astronauts and others to maintain muscle and bone strength and endurance in low-gravity environments, the ARED could also prove advantageous in terrestrial settings (e.g., health clubs and military training facilities) in which many users are exercising simultaneously and there is heavy demand for use of exercise machines.

Posted in: Bio-Medical, Medical, Briefs

Read More >>

Rapid Engineering of Three-Dimensional, Multicellular Tissues With Polymeric Scaffolds

Engineered tissues could be grown in weeks or days instead of months. A process has been developed for the rapid tissue engineering of multicellular- tissue-equivalent assemblies by the controlled enzymatic degradation of polymeric beads in a low-fluid- shear bioreactor. In this process, the porous polymeric beads serve as temporary scaffolds to support the assemblies of cells in a tissuelike 3D configuration during the critical initial growth phases of attachment of anchorage-dependent cells, aggregation of the cells, and formation of a 3D extracellular matrix. Once the cells are assembled into a 3D array and enmeshed in a structural supportive 3D extracellular matrix (ECM), the polymeric scaffolds can be degraded in the low-fluid-shear environment of the NASA-designed bioreactor. The natural 3D tissuelike assembly, devoid of any artificial support structure, is maintained in the low-shear bioreactor environment by the newly formed natural cellular/ECM. The elimination of the artificial scaffold allows normal tissue structure and function.

Posted in: Medical, Briefs

Read More >>

Ultraviolet-Resistant Bacterial Spores

A document summarizes a study in which it was found that spores of the SAFR-032 strain of Bacillus pumilus can survive doses of ultraviolet (UV) radiation, γ radiation, and hydrogen peroxide in proportions much greater than those of other bacteria. The study was part of a continuing effort to understand the survivability of bacteria under harsh conditions and develop means of sterilizing spacecraft to prevent biocontamination of Mars that could interfere with the search for life there.

Posted in: Medical, Briefs

Read More >>

Effects of Bone Morphogenic Proteins on Engineered Cartilage

A report describes experiments on the effects of bone morphogenic proteins (BMPs) on engineered cartilage grown in vitro. In the experiments, bovine calf articular chondrocytes were seeded onto biodegradable polyglycolic acid scaffolds and cultured in, variously, a control medium or a medium supplemented with BMP-2, BMP-12, or BMP-13 in various concentrations. Under all conditions investigated, cell-polymer constructs cultivated for 4 weeks macroscopically and histologically resembled native cartilage. At a concentration of 100 ng/mL, BMP-2, BMP-12, or BMP-13 caused (1) total masses of the constructs to exceed those of the controls by 121, 80, or 62 percent, respectively; (2) weight percentages of glycosaminoglycans in the constructs to increase by 27, 18, or 15, respectively; and (3) total collagen contents of the constructs to decrease to 63, 89, or 83 percent of the control values, respectively. BMP-2, but not BMP-12 or BMP-13, promoted chondrocyte hypertrophy.

Posted in: Medical, Briefs

Read More >>

High-Speed Noninvasive Eye-Tracking System

This system operates at a frame rate of several kilohertz. The figure schematically depicts a system of electronic hardware and software that noninvasively tracks the direction of a person’s gaze in real time. Like prior commercial noninvasive eye-tracking systems, this system is based on (1) illumination of an eye by a low-power infrared light-emitting diode (LED); (2) acquisition of video images of the pupil, iris, and cornea in the reflected infrared light; (3) digitization of the images; and (4) processing the digital image data to determine the direction of gaze from the centroids of the pupil and cornea in the images. Relative to the prior commercial systems, the present system operates at much higher speed and thereby offers enhanced capability for applications that involve human-computer interactions, including typing and computer command and control by handicapped individuals, and eye-based diagnosis of physiological disorders that affect gaze responses.

Posted in: Bio-Medical, Medical, Briefs

Read More >>

Detergent-Specific Membrane Protein Crystallization Screens

A suite of reagents has been developed for three-dimensional crystallization of integral membranes present in solution as protein-detergent complexes (PDCs). The compositions of these reagents have been determined in part by proximity to the phase boundaries (lower consolute boundaries) of the detergents present in the PDCs. The acquisition of some of the requisite phase-boundary data and the preliminary design of several of the detergent- specific screens was supported by a NASA contract. At the time of expiration of the contract, a partial set of preliminary screens had been developed. This work has since been extended under non-NASA sponsorship, leading to near completion of a set of 20 to 30 different and unique detergent-specific 96-condition screens.

Posted in: Medical, Briefs

Read More >>

White Papers

Tubing & Hose Buying Tips
Sponsored by Newage Industries
How Paper-based 3D Printing Works: The Technology and Advantages
Sponsored by Mcor Technologies
A Brief History of Modern Digital Shaker Controllers
Sponsored by Crystal Instruments
Performance Characteristics of Digital Frequency Discriminators
Sponsored by Wide Band Systems
An Introduction to Stress Analysis and Transducer Design Using Strain Gauges
Sponsored by HBM
Liquid Silicone Rubber Takes the Heat
Sponsored by Proto Labs

White Papers Sponsored By: