Health, Medicine, & Biotechnology

Electrochemical Detection of Multiple Bioprocess Analytes

Key analytes can be detected using sample volumes of only 100 mL.

An apparatus that includes highly miniaturized thin-film electrochemical sensor array has been demonstrated as a prototype of instruments for simultaneous detection of multiple substances of interest (analytes) and measurement of acidity or alkalinity in bioprocess streams. Measurements of pH and of concentrations of nutrients and wastes in cell-culture media, made by use of these instruments, are to be used as feedback for optimizing the growth of cells or the production of desired substances by the cultured cells. The apparatus is designed to utilize samples of minimal volume so as to minimize any perturbation of monitored processes.

Posted in: Briefs, MDB, TSP, Briefs, TSP, Bio-Medical, Medical, Patient Monitoring, Sensors, Downsizing, Biological sciences, Product development, Biomaterials, Test equipment and instrumentation
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Custom Assembly Helps Create Medical-Grade Saline in Space

BioConnect® bag and tubing assemblies Cole-Parmer Instrument Vernon Hills, IL 800-323-4340 www.coleparmer.com

BioConnect custom bag and tubing assemblies supplied the materials and services to catalyze the production of a prototype for the Intravenous Fluid Generation (IV Gen) technology demonstration on the International Space Station. Funded through NASA’s Human Research Program, a team from NASA’s Glenn Research Center (Cleveland, OH) and ZIN Technologies (Cleveland) seeks to produce medical-grade saline solution in a zero-gravity environment. If successful, the process solves the challenge of packing IV solution that expires during the shuttle cycle, and alleviates mass and volume storage constraints.

Posted in: Application Briefs, Medical, Medical equipment and supplies, Assembling
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Zinc-Doped Tricalcium Phosphate Ceramic for Surgical Implants

This material exhibits an osteogenesis-promoting effect without toxicity, making it suitable as a surgical implant.

A ceramic body consisting of the phases of tricalcium phosphate and/or hydroxyapatite provides biocompatibility with hard tissues. When such a ceramic body is implanted in a bone, direct connection is formed between the bone and the ceramic body without intervention of any fibrous connective tissues. This zinc-containing or zinc-doped ceramic material mainly consists of tricalcium phosphate and is suitable as a ceramic material for biomedical use. In particular, the material provides surgical implant materials for hard tissue consisting of zinc-doped tricalcium phosphate to promote bone formation by releasing zinc in the body.

Posted in: Briefs, MDB, Briefs, Coatings & Adhesives, Materials, Bio-Medical, Implants & Prosthetics, Medical, Prostheses and implants, Biomaterials, Calcium, Ceramics, Materials properties, Zinc alloys
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Micro-Electrode Visual Inspection System Utilizing Image Processing Tools

This system eliminates the need for manual inspections using microscopes.

A system was devised to aid in the inspection of micro-electrode assemblies utilized in clinical lab instruments to conduct impedance measurements on living cells in a 384 bottomless well casing with the electrode layer bonded to the housing, creating the closed-cell, real-time data acquisition instrument for assay tests.

Posted in: Briefs, MDB, Briefs, Imaging, Bio-Medical, Medical, Electronic equipment, Imaging and visualization, Inspections, Test equipment and instrumentation, Mining vehicles and equipment
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Power-Assist Control Interface for Wheelchairs

This technology monitors input and effort, and instantly adapts the device to real-world conditions.

A computer-controlled, programmable control interface allows safe, intuitive manual control for motorized wheelchairs that operate in variable terrain. The key feature of this technology is its proprietary computer program that enables an operator to manage a load as if it were light and on a smooth level surface, no matter what the real-world load or grade is. Operation is completely intuitive and does not require manipulation of throttle and/or brakes.

Posted in: Briefs, MDB, Briefs, Electronics, Electronics & Computers, Bio-Medical, Medical, Rehabilitation & Physical Therapy, Computer software and hardware, Electronic control systems, Terrain, Medical equipment and supplies
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Neuroprosthetics and Solutions for Restoring Sensorimotor Functions

A new class of prosthetic devices looks, feels, and functions like natural limbs.

Advances in body armor and life-saving technology have increased survival rates of severely injured military personnel. Unfortunately, the survivors of improvised explosive devices are often left with amputations and/or spinal cord injuries. The increase in amputations and paralysis among military personnel requires significant advances in prosthetics and functional electrical stimulation (FES) systems so that the soldiers can return to the field or to productive civilian lives.

Posted in: Briefs, MDB, TSP, Briefs, TSP, Coatings & Adhesives, Materials, Bio-Medical, Implants & Prosthetics, Medical
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Implantable Microsystems for Anatomical Rewiring of Brain Circuitry

This implantable device technology improves long-term functional recovery after a traumatic brain injury.

It has been demonstrated that after a stroke-like lesion in the cerebral cortex of non-human primates, the remaining intact tissue undergoes extensive neuro-physiological and neuroanatomical remodeling. The ability of cortical areas remote from the infarct to form new cortico-cortical connections over long distances between the frontal and parietal lobes has been demonstrated. It is likely that these novel connections play a role in functional recovery after cortical injury.

Posted in: Briefs, MDB, TSP, Briefs, TSP, Bio-Medical, Implants & Prosthetics, Medical, Rehabilitation & Physical Therapy, Diseases, Nervous system, Prostheses and implants, Head injuries
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Use of Recombinant Factor VIIa for Control of Combat-Related Hemorrhage

Recombinant rFVIIa may have a damage-control role, quickly arresting blood loss until the casualty can be evacuated to a hospital.

Blood loss is a major cause of death among combat casualties, accounting for nearly half of all deaths on the battlefield. The great majority of these deaths is due to intracavitary hemorrhage that cannot be controlled by traditional methods such as tourniquets or pressure dressings. Surgery remains the best method for controlling this type of hemorrhage and preventing death, although methods are needed to control bleeding until patients can get surgical intervention.

Posted in: MDB, Briefs, TSP, Bio-Medical, Drug Delivery, Medical, Fluids and secretions, Medical equipment and supplies, Injuries, Military vehicles and equipment, Rescue and emergency vehicles and equipment
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Biotic-Abiotic Interface Between the Body and an Artificial Limb

A modified titanium construct and specially machined surface increase adherence of tissue to a prosthetic limb.

Because of its high mechanical properties, chemical stability, and biocompatibility, titanium is a commonly used material in dental and orthopedic applications. Its excellent biocompatibility allows titanium implants to be directly anchored to bone, or osseo-integrated. The conventional prosthetic replacement in amputees is a stump-socket design, which transfers forces through the prosthetic to an external contact point on the patient. Such a design results in non-uniform distribution of pressure, and can lead to pain, infection, and necrosis of the soft tissues at the point of contact.

Posted in: MDB, Briefs, TSP, Coatings & Adhesives, Materials, Bio-Medical, Implants & Prosthetics, Medical, Prostheses and implants, Materials properties, Titanium, Biomechanics
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RF Device for Acquiring Images of the Human Body

This portable, simple system using a ring-shaped antenna array and planar circuit technology can serve as security in airports, mass transit locations, and power plants.

A safe, non-invasive method for forming images through clothing of large groups of people, in order to search for concealed weapons either made of metal or not, has been developed. A millimeter wavelength scanner designed in a unique, ring-shaped configuration can obtain a full 360° image of the body with a resolution of less than a millimeter in only a few seconds. Millimeter waves readily penetrate normal clothing, but are highly reflected by the human body and concealed objects. Millimeter wave signals are non-ionizing and are harmless to human tissues when used at low power levels.

Posted in: MDB, Briefs, TSP, Bio-Medical, Diagnostics, Medical, Antennas, Imaging and visualization, Integrated circuits, Security systems, Sensors and actuators, Human factors
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