Sensors

Ultrasonic Echo Probe With Measurement of Contact Pressure Distribution

This probe can measure tissue inside living bodies non-invasively using a thin-film piezoelectric pressure sensor.This ultrasonic echo apparatus can measure tissue inside living bodies, non-invasively. The developed probe has a film-like piezoelectric sensor installed on the contact surface of an ordinary medical ultrasonic probe, and it can measure the contact pressure distribution between the probe and living bodies. Since it can measure, with an ultrasonic echo image, the deformation of living bodies when a probe is pressed against them dynamically, it can calculate the distribution of mechanical impedance within living bodies by using information on contact pressure at the contact surface.

Posted in: Bio-Medical, Sensors, Medical, Briefs, Features, MDB

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Electrochemical Detection of Multiple Bioprocess Analytes

Key analytes can be detected using sample volumes of only 100 mL.An apparatus that includes highly miniaturized thin-film electrochemical sensor array has been demonstrated as a prototype of instruments for simultaneous detection of multiple substances of interest (analytes) and measurement of acidity or alkalinity in bioprocess streams. Measurements of pH and of concentrations of nutrients and wastes in cell-culture media, made by use of these instruments, are to be used as feedback for optimizing the growth of cells or the production of desired substances by the cultured cells. The apparatus is designed to utilize samples of minimal volume so as to minimize any perturbation of monitored processes.

Posted in: Bio-Medical, Sensors, Medical, Patient Monitoring, Briefs, MDB

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Magnetic Nanoparticles and Devices for Biomedical Uses

Potential applications include detecting selected biomolecules and treating some brain injuries.A program comprising several collaborative research efforts has been dedicated to advancing the art of utilization of magnetic nanoparticles for biomedical purposes. The research has been performed by three teams, each focusing on different aspects of the art:

Posted in: Bio-Medical, Treatment Devices, Materials, Coatings & Adhesives, Sensors, Medical, Briefs, MDB

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Vibrating Quartz Sensor Characterizes Liquid Samples

This technology eliminates the need to run multiple tests to obtain a sample profile. A novel analytical technology characterizes liquids for healthcare applications. As a drop of liquid evaporates on a vibrating quartz sensor, it undergoes distinctive phase changes representing the unique chemical and physical characteristics of the sample. This unique “fingerprint” represents information that is not readily available from any combination of analytical methods currently in use.

Posted in: Bio-Medical, Sensors, Medical, Patient Monitoring, Briefs, MDB

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Fluorogenic Cell-Based Biosensors for Monitoring Microbes

Fluorogenic cell-based sensor systems for detecting microbes (especially pathogenic ones) and some toxins and allergens are undergoing development. These systems harness the natural signaltransduction and amplification cascades that occur in mast cells upon activation with antigens. These systems include (1) fluidic biochips for automated containment of samples, reagents, and wastes and (2) sensitive, compact fluorometers for monitoring the fluorescent responses of mast cells engineered to contain fluorescent dyes. It should be possible to observe responses within minutes of adding immune complexes. The systems have been shown to work when utilizing either immunoglobulin E (IgE) antibodies or traditionally generated rat antibodies — a promising result in that it indicates that the systems could be developed to detect many target microbes. Chimeric IgE antibodies and rat immunoglobulin G (IgG) antibodies could be genetically engineered for recognizing biological and chemical warfare agents and airborne and food-borne allergens. Genetic engineering efforts thus far have yielded (1) CD14 chimeric antibodies that recognize both Gram-positive and Gram-negative bacteria and bind to the surfaces of mast cells, eliciting a degranulation response and (2) rat IgG2a antibodies that act similarly in response to low levels of canine parvovirus.

Posted in: Bio-Medical, Sensors, Medical, Briefs, MDB

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Sensory Feedback System for Prosthetic Hand Using Interferential Current

This sensory feedback system would help amputees execute fine tasks or handle delicate objects easily. A new type of sensory feedback system for a myoelectrically controlled biomimetic prosthetic hand was developed. One of the characteristic features of the human neuromuscular control system is the increase in the compliance around a joint with decreasing activity of a muscle. Interferential current that uses two waves and interferences was used to synthesize a low frequency in the body. One frequency was fixed at 4,000 Hz and the other frequency was changed from 3,700 Hz to 4,000 Hz. As a result, stimulus frequency in the body was changed from 0 Hz to 300 Hz. It was measured that the subjects could distinguish the change of stimulus frequency, and confirmed that the interference current is a useful method for sensibility feedback of a prosthetic hand.

Posted in: Bio-Medical, Sensors, Implants & Prosthetics, Medical, Briefs, MDB

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Microfluidic Mixing Technology for a Universal Health Sensor

A highly efficient means of microfluidic mixing has been created for use with the rHEALTH sensor — an elliptical mixer and passive curvilinear mixing patterns. The rHEALTH sensor provides rapid, handheld, complete blood count, cell differential counts, electrolyte measurements, and other lab tests based on a reusable, flow-based microfluidic platform.

Posted in: Bio-Medical, Sensors, Medical, Briefs, MDB

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