The benefits of applying a low sedimental fluid shear environment to manipulate microorganisms were examined. Microorganisms obtained from a low sedimental fluid shear culture, which exhibit modified phenotypic and molecular genetic characteristics, are useful for the development of novel and improved diagnostics, therapeutics, vaccines, and bio-industrial products. Furthermore, application of low sedimental fluid conditions to microorganisms permits identification of molecules uniquely expressed under these conditions, providing a basis for the design of new therapeutic targets.

This work was done by C. Mark Ott of Johnson Space Center; Cheryl A. Nickerson, James W. Wilson, and Shameema Sarker of Arizona State University; Eric A. Nauman of Purdue University; Michael J. Schurr of the University of Colorado Health Science Center; and Mayra A. Nelman-Gonzalez of Wyle Laboratories. For further information, see http://www.wipo.int/pctdb/en/wo.jsp?WO= 2009036036

In accordance with Public Law 96-517, the contractor has elected to retain title to this invention. Inquiries concerning rights for its commercial use should be addressed to:

Arizona State University
Center for Infectious Diseases and Vaccinology
P.O. Box 875401
Tempe, AZ 85587-5401
Phone No. (480) 727-7520
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