Health, Medicine, & Biotechnology

Enabling Microliquid Chromatography by Microbead Packing of Microchannels

The microbead packing is the critical element required in the success of onchip microfabrication of critical microfluidic components for in-situ analysis and detection of chiral amino acids. In order for microliquid chromatography to occur, there must be a stationary phase medium within the microchannel that interacts with the analytes present within flowing fluid. The stationary phase media are the microbeads packed by the process discussed in this work. The purpose of the microliquid chromatography is to provide a lightweight, low-volume, and low-power element to separate amino acids and their chiral partners efficiently to understand better the origin of life.

Posted in: Briefs, Medical, Biological sciences, Fabrication, Biomaterials
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On-Command Force and Torque Impeding Devices (OC-FTID) Using ERF

This technology is applicable as a rehabilitation or exercise device.

Various machines have been developed to address the need for countermeasures of bone and muscle deterioration when humans operate over extended time in space. Even though these machines are in use, each of them has many limitations that need to be addressed in an effort to prepare for human missions to distant bodies in the solar system.

Posted in: Briefs, TSP, Bio-Medical, Medical, Anthropometrics, Human factors, Medical, health, and wellness, Electrohydraulics, Pistons, Biomechanics
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RECOVIR Software for Identifying Viruses

Most single-stranded RNA (ssRNA) viruses mutate rapidly to generate a large number of strains with highly divergent capsid sequences. Determining the capsid residues or nucleotides that uniquely characterize these strains is critical in understanding the strain diversity of these viruses. RECOVIR (an acronym for “recognize viruses”) software predicts the strains of some ssRNA viruses from their limited sequence data. Novel phylogenetic-treebased databases of protein or nucleic acid residues that uniquely characterize these virus strains are created. Strains of input virus sequences (partial or complete) are predicted through residue-wise comparisons with the databases.

Posted in: Briefs, Medical, Software, Computer software / hardware, Computer software and hardware, Computer software / hardware, Computer software and hardware, Medical, health, and wellness, Identification
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On-Command Force and Torque Impeding Devices (OC-FTID) Using ERF

This technology is applicable as a rehabilitation or exercise device.

Various machines have been developed to address the need for countermeasures of bone and muscle deterioration when humans operate over extended time in space. Even though these machines are in use, each of them has many limitations that need to be addressed in an effort to prepare for human missions to distant bodies in the solar system.

Posted in: Briefs, MDB, Briefs, Bio-Medical, Medical, Rehabilitation & Physical Therapy, Kinematics, Medical, health, and wellness, Pistons, Biomechanics, Spacecraft
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Rapid Detection of Herpes Viruses for Clinical Applications

There are eight herpes viruses that infect humans, causing a wide range of diseases resulting in considerable morbidity and associated costs. Varicella zoster virus (VZV) is a human herpes virus that causes chickenpox in children and shingles in adults. Approximately 1,000,000 new cases of shingles occur each year; post-herpetic neuralgia (PHN) follows shingles in 100,000 to 200,000 people annually. PHN is characterized by debilitating, nearly unbearable pain for weeks, months, and even years. The onset of shingles is characterized by pain, followed by the zoster rash, leading to blisters and severe pain. The problem is that in the early stages, shingles can be difficult to diagnose; chickenpox in adults can be equally difficult to diagnose. As a result, both diseases can be misdiagnosed (false positive/negative).

Posted in: Briefs, Medical, Data Acquisition, Diagnosis, Diseases, Nervous system
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Detection of Only Viable Bacterial Spores Using a Live/Dead Indicator in Mixed Populations

This technology can be used by the food and pharmaceutical industries to validate sterility and quality.

This method uses a photoaffinity label that recognizes DNA and can be used to distinguish populations of bacterial cells from bacterial spores without the use of heat shocking during conventional culture, and live from dead bacterial spores using molecular-based methods.

Posted in: Briefs, Medical, Bacteria
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Intravenous Fluid Generation System

This system can be used in remote medical facilities where limitations such as lack of refrigeration may limit the type and volume of medical fluids being stored or transported.

The ability to stabilize and treat patients on exploration missions will depend on access to needed consumables. Intravenous (IV) fluids have been identified as required consumables. A review of the Space Medicine Exploration Medical Condition List (SMEMCL) lists over 400 medical conditions that could present and require treatment during ISS missions.

Posted in: Briefs, Medical, Medical, health, and wellness, Spacecraft
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Plastic Optic Fiber—An Evolving Technology

POF technology has much to offer to the device industry.

Plastic Optic Fiber (POF) is an established, continually evolving technology available since the early 1980s. From the outset, it was a technology not highly visible for years. At times, it was utilized as a media product within another product, attached to a variety of opto-couplers or light sources. Primarily it was intended to transmit information of functional digital data transfer for many sensing concepts and for small form illumination. In addition, the very nature of POF technology brings to engineering many of the attributes of glass fiber optic technology. But, the extensive functions of POF lend themselves to much wider product uses including medical instruments, data control and networks, automotive use, and a host of industrial concepts. At the same time, POF offers low-cost solutions for short-range communications, and a majority of defined illumination requirements.

Posted in: Briefs, MDB, Briefs, Lighting, Custom & Contract Manufacturing, Materials, Plastics, Inspection Equipment, Medical, Fiber Optics, Optical Components, Optics, Photonics, Robotics, Data acquisition and handling, Fiber optics, Data acquisition and handling, Fiber optics, Medical equipment and supplies, Plastics
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Electron Beam Writer Enables Microfabrication

Integrated electronics could activate prosthetics.

The new electron beam writer housed in the cleanroom facility at the Qualcomm Institute, previously the UCSD division of the California Institute of Telecommunications and Information Technology, is important for two major areas of research by Shadi Dayeh, PhD, an electrical and computer engineering professor. He is developing next-generation, nanoscale transistors for integrated electronics. At the same time, he is working to develop neural probes that can extract electrical signals from brain cells and transmit the information to a prosthetic device or computer. To achieve this level of signal extraction or manipulation requires tiny sensors spaced very closely together for the highest resolution and signal acquisition. Enter the new electron beam writer. (See Figure 1)

Posted in: Briefs, MDB, Briefs, Electronics, Electronics & Computers, Implants & Prosthetics, Medical, Patient Monitoring, Optics, Photonics, Semiconductors & ICs, Sensors, Semiconductor devices, Sensors and actuators, Semiconductor devices, Sensors and actuators, Nervous system, Prostheses and implants, Fabrication, Nanotechnology
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Enabling Microliquid Chromatography by Microbead Packing of Microchannels

The microbead packing is the critical element required in the success of onchip microfabrication of critical microfluidic components for in-situ analysis and detection of chiral amino acids. In order for microliquid chromatography to occur, there must be a stationary phase medium within the microchannel that interacts with the analytes present within flowing fluid. The stationary phase media are the microbeads packed by the process discussed in this work. The purpose of the microliquid chromatography is to provide a lightweight, low-volume, and lowpower element to separate amino acids and their chiral partners efficiently to understand better the origin of life.

Posted in: Briefs, MDB, TSP, Briefs, TSP, Coatings & Adhesives, Materials, Fluid Handling, Diagnostics, Imaging, Medical, Patient Monitoring, Optics, Photonics, Measuring Instruments, Imaging, Imaging and visualization, Imaging, Imaging and visualization, Biological sciences, Biomaterials, Test equipment and instrumentation
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