Health, Medicine, & Biotechnology

Bionanomatrix Coating Boosts Biocompatibility of Implants

A patent-pending, natural, self-assembling technology could overcome problems associated with the body’s rejection of prosthetics and implants.

Cardiovascular stents and other medical implants increase lifespan and quality of life for millions around the world — yet adverse effects attenuate their full potential. Bionanomatrix coatings for such devices can vastly improve long-term outcomes.

Posted in: Briefs, MDB, Briefs, Coatings & Adhesives, Materials, Bio-Medical, Implants & Prosthetics, Medical, Cardiovascular system, Prostheses and implants, Coatings Colorants and Finishes, Coatings, colorants, and finishes

Thermal Management Solutions for Medical Applications

Thermoelectric Assemblies (TEAs) offer precise temperature control for applications with tight space constraints and low weight requirements.

Thermal management of medical electronic devices and systems is now more challenging. Power densities continue to increase while product form factors continue to shrink. Simple thermal management solutions, such as passive cooling (adding a fan and heat sink), are no longer typically viable to meet required performance and reliability specifications. In today’s complex medical operating environment, Thermo electric Assemblies (TEAs) are necessary to provide precise temperature control via cooling and heating in a variety of modular platforms.

Posted in: Briefs, MDB, Briefs, Electronics, Electronics & Computers, Bio-Medical, Medical, Patient Monitoring, Medical equipment and supplies, Thermal management, Thermal management

High-Resolution Ophthalmic Ultrasound System for Ocular Structures

This technology may be used to obtain a critical view of the posterior segment of the eye when a dense cataract or vitreous hemorrhage is present.

An ophthalmic ultrasound system evaluates ocular structures more clearly by providing images of all aspects of the anterior segment. It provides images of the eye and tissues around and behind the eye to determine the presence of pathology when doctors are prohibited from viewing it directly due to opacity of the cornea, lens, or the vitreous gel that fills the eye.

Posted in: Briefs, MDB, Briefs, Bio-Medical, Diagnostics, Medical, Imaging, Imaging and visualization, Imaging, Imaging and visualization, Body regions, Diagnosis

Improved Devices for Collecting Sweat for Chemical Analysis

Unlike prior devices, these would enable measurement of volumes of specimens.

Improved devices have been proposed for collecting sweat for biochemical analysis — especially for determination of the concentration of Ca2+ ions in sweat as a measure of loss of Ca from bones. Unlike commercially available sweat-collection patches used previously in monitoring osteoporosis and in qualitative screening for some drugs, the proposed devices would not allow evaporation of the volatile chemical components (mostly water) of sweat. Moreover, the proposed devices would be designed to enable determination of the volumes of collected sweat. From these volumes and the quantities of Ca2+ and/or other analytes as determined by other means summarized below, one could determine the concentrations of the analytes in sweat.

Posted in: Briefs, MDB, TSP, Briefs, TSP, Bio-Medical, Medical, Patient Monitoring, Analysis methodologies, Medical equipment and supplies

Post-Fragmentation Whole Genome Amplification-Based Method

This method has application in hospital cleanliness validation assays, pharmaceutical development, and medical device manufacturing and packaging.

This innovation is derived from a proprietary amplification scheme that is based upon random fragmentation of the genome into a series of short, overlapping templates. The resulting shorter DNA strands (

Posted in: Briefs, Bio-Medical, Medical, Biological sciences, Medical equipment and supplies, Pharmaceuticals, Test procedures

Microwave Tissue Soldering for Immediate Wound Closure

Wounds can be closed rapidly, without staples, sutures, or tapes.

A novel approach for the immediate sealing of traumatic wounds is under development. A portable microwave generator and handheld antenna are used to seal wounds, binding the edges of the wound together using a biodegradable protein sealant or “solder.” This method could be used for repairing wounds in emergency settings by restoring the wound surface to its original strength within minutes. This technique could also be utilized for sur-gical purposes involving solid visceral organs (i.e., liver, spleen, and kidney) that currently do not respond well to ordinary surgical procedures.

Posted in: Briefs, Bio-Medical, Medical, Antennas, Antennas, Medical equipment and supplies, Adhesives and sealants, Injuries, Radiation, Rescue and emergency vehicles and equipment

Stress-Driven Selection of Novel Phenotypes

A methodology allows the experimental design of novel peptides and RNAs that have desired properties.

A process has been developed that can confer novel properties, such as metal resistance, to a host bacterium. This same process can also be used to produce RNAs and peptides that have novel properties, such as the ability to bind particular compounds. It is inherent in the method that the peptide or RNA will behave as expected in the target organism. Plasmid-born mini-gene libraries coding for either a population of combinatorial peptides or stable, artificial RNAs carrying random inserts are produced. These libraries, which have no bias towards any biological function, are used to transform the organism of interest and to serve as an initial source of genetic variation for stress-driven evolution.

Posted in: Briefs, Bio-Medical, Medical, Biological sciences

Principles, Techniques, and Applications of Tissue Microfluidics

This technique can be used in the diagnosis of diseases such as cancer.

The principle of tissue microfluidics and its resultant techniques has been applied to cell analysis. Building microfluidics to suit a particular tissue sample would allow the rapid, reliable, inexpensive, highly parallelized, selective extraction of chosen regions of tissue for purposes of further biochemical analysis. Furthermore, the applicability of the techniques ranges beyond the described pathology application. For example, they would also allow the posing and successful answering of new sets of questions in many areas of fundamental research.

Posted in: Briefs, Bio-Medical, Medical, Medical, health, and wellness, Research and development

Robotic Scaffolds for Tissue Engineering and Organ Growth

Biocompatible and biodegradable smart scaffolds could reconfigure their shape and size to accommodate organ development.

The aim of tissue engineering (TE) is to restore tissue and organ functions with minimal host rejection. TE is seen as a future solution to solve the crisis of donor organs for transplant, which faces a shortage expected only to increase in the future. In this innovation, a flexible and configurable scaffold has been conceived that mechanically stresses cells that are seeded on it, stimulating them to increased growth.

Posted in: Briefs, Bio-Medical, Medical, Anatomy, Prostheses and implants, Robotics, Biomaterials, Nanotechnology

Meet Our Readers: Michael Hudspeth, CAD Designer, Medical Devices

In a new series, the editors of NASA Tech Briefs magazine catch up with everyday engineers about their unique responsibilities and challenges. This week, we highlight fellow reader and CAD designer of medical devices, Michael Hudspeth.

Posted in: Articles, Medical, CAD / CAM / CAE, CAD, CAM, and CAE, Medical equipment and supplies, People and personalities

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