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Making the Compliance Grade: Quantitative View on Compliance Management

Whether building enterprise-level solutions, using cloud-based solutions, or even building in-house solutions, the dynamic of automation is a key component in the compliance market. VERSE gauged the common challenges in compliance around Quality and Safety and compiled the results in this compliance grader white paper.

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4 Steps In Selecting Fluid Connectors For Medical Device And Equipment Applications

With so many risks and options for connecting tubing in medical applications, it is important to have a simple and repeatable strategy for selecting the best connector solution. The process requires a thorough analysis of the application in order to ensure connectors will be compatible with the physical, chemical and biological environment, and be easy to use and help prevent misconnections—whether the application involves connecting air lines for a blood pressure cuff, connecting reagent supplies to a blood analyzer or making critical connections between a patient and heart-lung machine.

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Relativistic Ion Tracks (RITRACKS)

Lyndon B. Johnson Space Center, Houston, Texas Once astronauts venture beyond Earth’s protective atmosphere, they are exposed to the high-energy charged particles of galactic cosmic rays (GCR) and solar particle events (SPE), and secondary protons and neutrons. GCR are composed of ions, the great majority of which are protons (≈87%) and helium nuclei (≈12%). The heavy ions of atomic number greater than 2 comprise only a small fraction of the charged particles in the GCR, but they contribute significantly to the radiation dose and dose equivalent over time. Because of their ionization patterns in biomolecules, cells and tissues are distinct from terrestrial radiation, the resulting biological effects are poorly understood, and the health risks of these radiations are subject to large uncertainties.

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Medical Oxygen Concentrator for Microgravity Operation

Only ambient air and DC energy are required to operate the system. John H. Glenn Research Center, Cleveland, Ohio Supplemental oxygen delivery systems are vital to provide a critical life support respiratory function. Whether they are used for patients suffering from lung diseases or other illnesses, or astronauts donning an oxygen mask during a toxic spill or fire on a spacecraft, lightweight and portable oxygen delivery systems are in high demand. A lightweight portable oxygen concentrator was developed that can produce 1 to 6 lpm of pulse oxygen in a noiseless system that can be worn on the user’s hip or in a shoulder sling.

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Lateral Displacement Device for Blood Cell Separation

This device has side microchannels where the particles are separated and collected. Lyndon B. Johnson Space Center, Houston, Texas Separation of particles based on size is one of the essential components in biochemical analysis, environmental assays, and industrial and biomedical applications. Filtration is one of the most frequently used techniques to separate particles. A mechanical filter can be used to remove, filter, or collect particles. This filtering and collection of particles can be used for sampling of particles, chemical detection, and/or biological cell analysis.

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Using a Blood Clot in Microfluidic Valving Applications

This type of valve is satisfactory for most microfluidic applications for on-chip blood analysis. Lyndon B. Johnson Space Center, Houston, Texas The lack of reliable microvalves impedes many lab-on-a-chip applications for blood analysis. On the other hand, blood clotting — the formation of solid blood aggregate to stop bleeding — provides a natural valving mechanism. It is therefore very attractive to use this mechanism for microfluidic control when blood is available. In fact, the blood clot has many interesting mechanical properties. For example, the fibrin fibers in blood clots have extensibility as high as 330% and an elastic modulus around 8 MPa. However, the study of implementing blood clots as an engineering material, especially in the MEMS area, is lacking.

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Drug-Encapsulated Prosthetic Enhancement

Lyndon B. Johnson Space Center, Houston, Texas This invention places a drug delivery system inside a prosthetic implant to circumvent the physical issues encountered after fitting the implant. Implants being relatively large in size would be able to house the drug-carrying device inside them without compromising the structural integrity or the functionality of the prostheses. Capsules containing multiple reservoirs filled with different drugs could be released simultaneously. This application could further be extended to using such drug-carrying capsules in cardiovascular stents through which slow and sustained release of drugs could be achieved to prevent inflammation in the short term, and restenosis in the long term. Once the capsule has drained out, the drug inside will remain in the implant and can be considered a part of the implant for the future. The implant reservoir may also be refilled via minor surgery until needed.

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