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Provision of Carbon Nanotube Buckypaper Cages for Immune Shielding of Cells, Tissues, and Medical Devices

This method may prevent the rejection of transplanted cells and tissue. Ames Research Center, Moffett Field, California NASA has patented a new technology that may prevent the rejection of transplanted cells and tissues. The human immune system identifies and rejects non-host cells and tissues with high efficiency. The new invention involves the fabrication and use of carbon nanotube buckypaper (CNTBP) “cages” for immune shielding. This approach promotes and supports a variety of useful biological processes that are difficult or impossible when cells or tissue are maintained in culture outside the body. It allows for the transplantation of cells or tissues from unrelated donors or from unrelated species (xenografts) into host subjects with dramatically reduced potential for rejection and/or the use of immunosuppressive therapies, which can be highly toxic. Current strategies for islet cell transplantation, for example, have shown marginal success due to limited graft survival, even with immunosuppressive therapy.

Posted in: Briefs

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Rapid Polymer Sequencer

Maximum resolution will be improved at least 100-fold compared to biological ion-channel measurements. Ames Research Center, Moffett Field, California Solid-state, nanopore-based analysis of nucleic acid polymers is the only technique that can determine information content in single molecules of genetic material at the speed of 1 subunit per microsecond. Because individual molecules are counted, the output is intrinsically quantitative. The nanopore approach is more generalized than any other method, and in principle may be used to analyze any polymer molecule, including proteins. The approach to the development of a solid-state nanopore device is novel in the use of nanofabrication, nanoelectric components, and high-speed signal acquisition.

Posted in: Briefs

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High-Density, Homogenous Bacterial Spore Distributions on Test Surfaces

This method uses polycarbonate membrane to transfer spores onto a mirror surface. NASA’s Jet Propulsion Laboratory, Pasadena, California Thus far, spore transfer had been successful from the polycarbonate membrane onto stainless steel, aluminum, and to some extent, glass. In order to image the endospores under an ESEM (environmental scanning electron microscope), the spores were transferred onto a 4-mm-diameter, mirror-polished, stainless steel ESEM tab. For the spectroscopic and irradiation procedures in the Planetary Ice Group, it has also been necessary to transfer a highly concentrated, homogenous layer of spores onto a 1/2- or 1-in. (≈1.3- or 2.5-cm) aluminum mirror. Various other methods have been developed and tested for statistical spore deposition and transfer, but transfer was previously prone to uneven coverage due to poor contact, as well as visible microdroplets from over-saturation of the backing filter contact or non-homogeneity on a larger scale. A complete, reproducible method follows to avoid these issues and ensure quantitative predictions and uniformity.

Posted in: Briefs

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Team Game and Simulation Control

Langley Research Center, Hampton, Virginia This technology is an offshoot of LaRC-developed technologies using physiological measures for assessing pilot stress, sustained attention, engagement, and awareness in a laboratory flight simulation environment. The technology allows modulation of player inputs to a video game or simulation from a user interface device based on the player’s psychophysiological state. It exploits current wireless motion-sensing technologies to utilize physiological signals for input modulation. These signals include, but are not limited to, heart rate, muscle tension, and brain wave activity. The invention is a technology for training teams to maintain functional states that are conducive to effective performance of manual tasks such as flight control, by physiologically modulating operator input devices to simulations. The invention also permits individuals who are physically challenged to participate in electronic game play by collaborating with a player who is able to manipulate controls that the challenged player cannot, and enables individuals with different skill sets and interests (physiological self-control vs. physical performance skills) to join together in rewarding game play. Besides gaming, this technology has application in athletic training and mind-body medicine.

Posted in: Briefs, TSP

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CRP Aptamers to Bone-Specific Alkaline Phosphatase (BAP)

Lyndon B. Johnson Space Center, Houston, Texas In order to detect and quantify bone-specific alkaline phosphatase (BAP) in a human biological sample, a binding agent (molecule) that specifically recognizes BAP in a sample is typically required. This binding agent can then be used in numerous assays/instruments to enable the detection and quantification of BAP.

Posted in: Briefs, TSP

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Breaking Boundaries: Bioabsorbable Polymers in Device Design

It is well known that programming the performance of a bioabsorbable medical device is paramount to its success. But did you know that a large part of this programming takes place at the component level?

Posted in: Webinars, On-Demand Webinars

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Medical 3D Printing and Additive Manufacturing: Going From Why to How

3D printing has been utilized in the medical industry for over 20 years. In recent years, the number of applications, utilization, and utility have increased exponentially. This increase has been driven by two key factors: (1) crossing the chasm from “how to print” to “why adopt 3D printing and additive manufacturing”, and (2) the dramatically increased selection of technologies and materials that meet the needs of medical professionals.

Posted in: Webinars, On-Demand Webinars

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