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Bayesian Sleep Fusion

This tool can be adapted to track fatigue levels of individuals in occupations associated with high levels of exhaustion or periods of circadian misalignment. Lyndon B. Johnson Space Center, Houston, Texas To ensure mission success, astronauts must maintain a high level of performance, even when work-rest schedules result in chronic sleep restriction and circadian misalignment, both of which can contribute to fatigue and performance deficits unless effective countermeasures are used. The overarching goal of this project is to build an Individualized Fatigue Meter to provide astronauts and mission support personnel with immediate feedback about their alertness or fatigue levels. The Individualized Fatigue Meter incorporates sleep history, ambient light levels, schedule information, and performance tests to provide immediate individualized feedback about alertness, and allow critical insight when making decisions about scheduling future sleep periods and selecting fatigue countermeasures.

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Technique for Reversible Permeabilization of Live Cells for Intracellular Delivery of Quantum Dots

Lyndon B. Johnson Space Center, Houston, Texas Nanomaterials are comparable in size to various biomolecules (1 to 100 nm), and have unique properties such as enhanced electrical conductivity, increased chemical reactivity, and novel optical properties that make them attractive candidates for various biomedical applications. Their comparable size and unique optical properties have been utilized to develop efficient tools for subcellular imaging and delivery of biomolecules. Traditional bimolecular delivery methods utilize plasmids, cationic polymers, lipids, and viruses that have inherent disadvantages such as degradation in physiological solutions, and the need for complex conjugation techniques.

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Introduction of Structural Affinity Handles as a Tool in Selective Nucleic Separations

Lyndon B. Johnson Space Center, Houston, Texas This invention relates to the general field of bio-chemical separations. Current methods for separating nucleic acids either lack sufficient selectivity or large-capacity production as required for gene therapy or DNA vaccines or other applications. There is a need for more selective methods of separating nucleic acids that results in a relatively uncontaminated product in larger volumes and yields than achieved with currently available separation methods.

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Functionalized Patterning of Tissue Engineering Substrates

Task also includes bioprinting cell-laden constructs for multi-compartment tissue chambers. Lyndon B. Johnson Space Center, Houston, Texas Tissue engineering (TE) is an emerging field for tissue repair and regeneration compared to conventional techniques including autograft and allograft, through engineering functional implants created from living cells. TE is a highly interdisciplinary research area where material science, engineering, and biology are blended to achieve tissue regeneration. Efforts have been made to regenerate liver, skin, bone, and vascular tissues by applying a tissue engineering approach. To generate any type of tissue in a laboratory environment, scientists need to mimic the cellular microenvironment by offering structural, chemical, physical, and biological cues to the cells. Introduction of these cues to the cellular environment starts with manufacturing a supportive matrix called a scaffold.

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Hearing Test System Suitable for Self-Administered Hearing Assessment

Lyndon B. Johnson Space Center, Houston, Texas Astronauts have developed hearing loss in space, so the goal of this project was to provide a robust, self-administered, accurate noise-tolerance hearing test system for astronauts. The device includes Bekesy-like threshold audiometry, distortion product otoacoustic emission testing, and gap-detection testing.

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Assessment of Microbial Bioburden Within Aerogel Matrices

A post-capture aerogel degradation via cryogenic grinding is compatible with downstream nucleic-acid-based molecular modes of analysis. NASA’s Jet Propulsion Laboratory, Pasadena, California A makeshift apparatus has been designed composed of a sealed, hydrophobic 2-propanol/SiO2 aerogel component to filter outside air particles. Following verification and assessment, the apparatus was crafted with a Buchner funnel. Aerogel matrices were tightly fitted into filter housings and secured in side-arm flasks, which were then equipped to a vacuum pump to pull air through the aerogel matrices. Aerogels, both with and without fiberglass reinforcement, were used to collect airborne particulates for one- and three-hour increments. An untreated negative control aerogel, employing air collection from a laminar hood, and a positive aerogel matrix were seeded with endospores that verified the extraction from the matrices.

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Using Electromagnetic Time-Variance Magnetic Fields to Generate and Re-Grow Cartilage

Lyndon B. Johnson Space Center, Houston, Texas Adevice provides electromagnetic pulses at a predetermined frequency that will result in cartilage cell regeneration and regrowth for patients with arthritis, which reduces or eliminates joint cartilage. The device can be wrapped around the joints in a patient where infected cartilage is located. Molecular and marker data have shown this innovation to work as described above. This is a non-invasive technology that regenerates the patient’s own tissue, allowing for possibly no significant side-effects or foreign matter reactivity.

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