The Rapid Automated Modular Microscope (RAMM) system from Applied Scientific Instrumentation (Eugene, OR) offers a modular design with automated high-speed XY stages, precision piezo and motorized Z focusing, along with a range of scanning options. It is configurable with infinity-corrected optics, dichroic filter cubes, multi-wavelength excitation and emission filterwheels, shutters, and detectors, including cameras and photomultipliers. A wide range of features can be added, including auto-focus, focus stabilization, tracker, and robotic specimen loader. It is suitable for applications in high throughput screening, genetic sequencing, and experimental research. It is designed using high MTBF components to reduce cost.