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Drug-Delivery Capsule Coated with Microneedles Could Replace Injections

Researchers at MIT and Massachusetts General Hospital have devised a novel drug capsule coated with microneedles that can inject drugs directly into the lining of the stomach after the capsule is swallowed. An ingestible capsule would contain a drug reservoir to house the therapeutic payload and have a pH-responsive coating to cover the microneedles for easy ingestion. After ingestion, the pill would pass through the stomach and enter the intestine. There, the coating would dissolve, revealing the microneedles. The motion of the tissue would compress the reservoir, expelling the drug out of the needles and into the tissue.

Topics:
Drug Delivery Medical

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    Transcript

    00:00:00 the use of micro needles in the gastrointestinal tract presents a unique opportunity to enable the oral delivery of large molecules like insulin that are currently limited to injection an ingestible capsule such as the one shown Could Be Imagined it would contain a reservoir to house the therapeutic payload and have a pH responsive coating to cover the needles allowing for easy

    00:00:23 ingestion after ingestion the pill would pass through the stomach and enter the intestine there the coating would dissolve revealing the micro needles the peristaltic motion of the tissue would compress the reservoir expelling the drug out of the needles and into the tissue insulin injections were tested in the GI tract of pigs as a result of injection a small bubble can be seen in

    00:00:44 the tissue this small injection results in a robust drop in the animal's blood glucose that's superior to the effect elicited by traditional subcutaneous injection oral Administration as expected has no effect the safety and passage of this model device was also tested in pigs the model device was placed through an over tube into the stomach of pigs

    00:01:11 once in the stomach it was released by looking for the radiographic image of the pill shown here the progress of the pill through the animal can be tracked by serial x-ray the pill was found to be safe and well tolerated