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Duke University’s Universal Flu Vaccine

Duke University is working on an improved flu vaccine that you get once and then you're essentially protected for a longer amount of time — or hopefully for forever. Watch this video to learn more about the Universal Flu Vaccine.

“On the virus particle, there's five to 10 times more hemagglutinin than neuraminidase,” said Nicholas Heaton  , PhD, an associate professor of molecular genetics and microbiology at Duke who led the research. “If we took your blood to see if are you likely to be protected from a strain of flu, we'd be measuring what your antibodies do to hemagglutinin as the best metric of what's likely to happen to you. The strongest correlates of protection have to do with hemagglutinin-directed immunity.”

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    Transcript

    00:00:00 foreign Universal flu vaccine is an improved influenza vaccine that you just get once and then you're essentially protected for a longer amount of time or hopefully for forever [Music] Duke an amazing environment for us to do this work we're embedded around a number of other investigators really thinking

    00:00:30 about the mechanisms of how these viruses cause disease at the same time we're plugged into like the Duke human vaccine Institute so we can take kind of the basic mechanistic observations that we're making about how the virus does what it does and really interact with people who think about how to make vaccines based on that and how to get that ultimately to the clinic there's a

    00:00:49 lot of different approaches that different people are trying in order to make this vaccine better essentially make it last for longer specifically what our vaccine is designed to do is change where the immune system focuses in response to the virus on the outside of the virus particle there's two proteins and what we're trying to do is basically trick the immune system to

    00:01:09 respond to different parts of the virus that it wouldn't normally do with the ideas that those parts are harder for the virus to change the protection would last for longer so the idea is if we make the immune response make antibodies to those two proteins you'll get protection so when you have a whole region like this those are all immune cells that are

    00:01:26 coming in to try and deal with the virus because the vaccine wasn't good enough to stop the virus from infecting in the first place in the lab the lab members will be actively growing viruses and cells then we will inactivate to test as candidate vaccines by some cells that I'll currently be splitting which which is kind of taking why the overall

    00:01:55 number of cells in the plate to let them grow better after we do an experimental vaccination we'll get back samples blood samples or cellular samples and then they'll be here in the lab basically understanding if our vaccine did better if we accomplished our goals right did we get more antibodies these antibodies bind into the different parts of the virus particle that we're trying to make

    00:02:16 happen