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The Bridge Recombination Mechanism — Next Generation Genome Design

Researchers have discovered the bridge recombinase mechanism, a precise and powerful tool to recombine and rearrange DNA in a programmable way. Going far beyond programmable genetic scissors like CRISPR, the bridge recombinase mechanism enables scientists to specify not only the target DNA to be modified, but also the donor material to be recognized, so they can insert new, functional genetic material, cut out faulty DNA, or invert any two sequences of interest. "The bridge RNA system is a fundamentally new mechanism for biological programming," said Hsu, senior author of the study  .

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