Andor Technology (South Windsor, CT) has introduced the iXonEM + EMCCD camera that can detect single photon events without an image intensifier. It offers photon collection efficiencies of up to 95% QE, readout speeds up to 35 MHz, 14- and 16- bit digitization, and thermoelectric cooling to -100°C. The system’s vertical clock parameters provide low spurious noise and minimal smear with short exposures. The camera is suitable for applications in single molecule detection, live-cell multi-dimensional microscopy, spinning disc confocal microscopy, intracellular ion signaling, cell motility, adaptive optics, photon counting, bioluminescence, neutron radiography, and spectral imaging.