A company is seeking new analgesic actives. Speed of effectiveness, toleration, and shelf-life are of particular interest. Analgesics vary in dosage load, dosage form, molecular size, speed of effectiveness, and side effects or toxicity. The form of the new proposed analgesic active is open to discussion. A minimum of pre-clinical data must exist.
New non-oral delivery mechanisms for analgesic medications are sought. These new mechanisms might be topical â€” in contact with the outer layer of the skin â€” but other non-oral mechanisms are also open for consideration. The amount of analgesic to be delivered per dose can vary. Molecule size and the hydrophilic or hydrophobic nature of the active and its medium also may play a part in uptake of the active. The proposed non-oral delivery mechanism will ideally work with a variety of actives.