The response of tumors to anticancer drugs has been observed in real-time, 3D images using technology developed at Purdue University. The new digital holographic imaging system uses a laser and a charged couple device (CCD) to see inside tumor cells. The instrument also may have applications in drug development and medical imaging.

"This is the first time holography has been used to study the effects of a drug on living tissue," said David D. Nolte, the Purdue professor of physics who leads the team. "We have moved beyond achieving a 3D image to using that image for a direct physiological measure of what the drug is doing inside cancer cells. This provides valuable information about the effects of various doses of the drug and the time it takes each dose to become significantly effective."

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