While widely used for terrestrial medical applications, handheld blood analyzers are not suitable for space missions due to the short shelf-life of their measurement cartridges as well as their lack of clinical-grade accuracy and sensitivity. Therefore, scientists researching the impact of spaceflight on humans often have access only to pre- and post-flight data. This also means that astronauts do not have a simple and reliable method to accurately, and in real time, monitor key health parameters during spaceflight. Clearly, an in situ measurement capability can provide significant benefits both to operations and spaceflight factors research, as well as in decision-making in managing astronauts’ health.

Photonic integrated circuit (PIC)-based biochemical sensors offer enhanced robustness and assay longevity compared with conventional portable analyzers. Under NASA Small Business Technology Transfer (STTR) funding, Silicon Valley-based Intelligent Fiber Optic Systems

Corporation (IFOS) and Stanford University are developing an innovative, miniaturized lab-on-a-chip device to directly monitor astronaut health during missions, using ~3 drops of body fluid sample such as blood, urine, and potentially other body fluids like saliva, sweat, or tears.

Figure 1. Integrated sensor schematic.

The first-generation system comprises a miniaturized biosensor based on PICs (including Vertical Cavity Surface Emitting Laser (VCSEL), photodetector and optical filters, as shown in Figure 1) and biochemical assay that generates a fluorescent optical signal change in response to the target analyte. This approach will enable simultaneous, multiplexed measurement capability using integrated microfluidic circuitry or standard microfluidic sample slides from the medical industry (Figure 2).

Figure 2. Multiplexed biochemical sensing platform.

The initial focus is on measurement of total protein concentration in blood and urine, the level of which can be indicative of liver and kidney conditions, infections, and bone marrow disorders. In experiments, a prototype lab-on-a-chip device demonstrated measurement performance better than gold-standard benchtop instruments including large benchtop spectrophotometer colorimetric assays. As shown in the model in Figure 2, the sensor capabilities will be extended to multiplex detection of other body fluids from which a number of analytes will be explored in accordance with NASA Human Research Program Exploration Medical Capability Element priorities. As an additional benefit, the envisioned PIC-based handheld biosensor platform (Figure 3) is an efficient and fieldable generic optical transducer that can be used cross-functionally to monitor water quality and other critical environmental parameters in space vehicles.

Figure 3. Envisioned handheld biochemical sensor platform for multiplexed measurements.

Johnson Space Center (JSC) in Houston, TX is interested in this technology due to its wide potential benefits to human spaceflight missions. IFOS is working with JSC's Human Research Program to explore technology infusion opportunities ranging from International Space Station (ISS) deployment, to future deep-space missions including Mars transit.

In parallel, to support wider commercialization here on Earth, IFOS participated in NASA's inaugural I-Corps™ program, in which the project team performed more than 100 in-person interviews with prospective customers, users, and stakeholders. The data collected indicates compelling business opportunities in personalized medicine and at-home diagnostics, both of which IFOS is now pursuing.

This article was written by Behzad Moslehi and William Price of Intelligent Fiber Optic Systems Corp. (Santa Clara, CA); James Harris and Fariah Mahzabeen of Stanford University (Palo Alto, CA); and Michael Krainak of NASA GSFC (Greenbelt, MD). For more information, please contact Dr. Krainak at This email address is being protected from spambots. You need JavaScript enabled to view it..


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This article first appeared in the September, 2018 issue of Tech Briefs Magazine.

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