Spider silk is useful for a variety of biomedical applications. It exhibits mechanical properties superior to synthetic fibers for tissue engineering, and it is not toxic or harmful to living cells.

One unexpected application for spider silk is its use in the creation of biocompatible lenses for biological imaging applications. A team of researchers from Tamkang University and National Yang-Ming University in Taiwan described the feasibility of creating lenses capitalizing on the properties of natural spider silk material. A spider can spin several different types of silks, each with different properties and functions. To create the spokes of their web, spiders use a type of silk known as dragline silk. It is an interesting natural material because of its significant features, such as high elasticity, great toughness, and large tensile strength. Compared to its weight, the strength of dragline silk is greater than steel.

The authors collected smooth, uniform dragline silk from Pholcus phalangioides spiders, commonly known as daddy longlegs, and dripped a resin onto the silk fiber. As the resin condensed on the fiber, the wetting properties of the silk naturally formed it into a dome shape, which they found could be used as an optical lens. The mechanical and optical properties of the silk also make it ideal for supporting the lens.

When they shined a laser onto the lens, it generated a high-quality photonic nanojet — a type of beam that can provide large-area, super-resolution imaging for biomedical applications. By tuning the length of time the silk spends under the resin drip, the size of the dome lens can be changed, allowing the photonic nanojets to be optimized for the desired type of imaging. The dome lens with flexible photonic nanojets is suitable for imaging nanoscale objectives at different depths within biological tissue.

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