A nanotube array based on vertically aligned nanotubes or carbon nanofibers has been invented for use in localized electrical stimulation and recording of electrical responses in selected regions of an animal body, especially including the brain. There are numerous established, emerging, and potential applications for localized electrical stimulation and/or recording, including treatment of Parkinson’s disease, Tourette’s syndrome, and chronic pain, and research on electrochemical effects involved in neurotransmission.
Carbon-nanotube-based electrodes offer potential advantages over metal macroelectrodes (having diameters of the order of a millimeter) and microelectrodes (having various diameters ranging down to tens of microns) heretofore used in such applications. These advantages include the following:
- Stimuli and responses could be localized at finer scales of spatial and temporal resolution, which is at subcellular level, with fewer disturbances to, and less interference from, adjacent regions.
- There would be less risk of hemorrhage on implantation because nanoelectrode- based probe tips could be configured to be less traumatic.
- Being more biocompatible than are metal electrodes, carbon-nanotubebased electrodes and arrays would be more suitable for long-term or permanent implantation.
- Unlike macro- and microelectrodes, a nanoelectrode could penetrate a cell membrane with minimal disruption. Thus, for example, a nanoelectrode could be used to generate an action potential inside a neuron or in proximity of an active neuron zone. Such stimulation may be much more effective than is extra- or intracellular stimulation via a macro- or microelectrode.
- The large surface area of an array at a micron-scale footprint of non-insulated nanoelectrodes coated with a suitable electrochemically active material containing redox ingredients would make it possible to obtain a pseudocapacitance large enough to dissipate a relatively large amount of electric charge, so that a large stimulation current could be applied at a micron-scale region without exhausting the redox ingredients.
- Carbon nanotube array is more compatible with the three-dimensional network of tissues. Particularly, a better electricalneural interface can be formed.
- A carbon nanotube array inlaid in insulating materials with only the ends exposed is an extremely sensitive electroanalysis tool that can measure the local neurotransmitter signal at extremely high sensitivity and temporal resolution.
A nanoelectrode array according to the invention (see figure) would include two or more microelectrode pads on an electrically insulating substrate. The sizes of the microelectrode pads and the distances between them could range from as little as about a micron to as large as hundreds of microns, the exact values depending on the intended use. Each microelectrode pad could be electrically addressed, either individually or in combination with one or more other pads for localized stimulation and/or recording. Each microelectrode pad would support either a stimulating or a recording electrode. In either case, the electrode would comprise a subarray of multiple nanoelectrodes in the form of carbon nanotubes electrically connected to, and protruding perpendicularly from, a metal contact layer on an electrically insulating substrate.
In the case of a stimulating electrode, the protruding portions of the carbon nanotubes would be treated to deposit a thin electro-active coating layer that would impart the desired amount of pseudocapacitance. Depending on the application, the exposed surface of the metal contact layer between the nanoelectrodes would be coated with an electrically insulating material (e.g., silica or a non-conductive polymer), or with an electrically conductive or electro-active polymer.