The present invention relates to the field of nanotechnology and, more particularly, to the field of delivery of active agents such as therapeutic and/or imaging agents using micro/nanoscale particles. Porous particles, such as porous silicon particles and porous silica particles, have a number of...

A promising strategy of early diagnosis is the detection of biological signatures (molecular biomarkers) from readily available body fluids, such as blood. However, the onset of most human diseases cannot be univocally identified on the basis of a single biomarker....

Leukocytes respond to toxic, infectious, and inflammatory processes to defend tissues and eliminate disease process or toxic challenge. Accurate and prompt counting and differentiation of leukocytes is critical for diagnoses of infection, leukemia, or allergy;...

Many diseases are accompanied by characteristic odors, and their recognition can provide diagnostic clues, guide the laboratory evaluation, and affect the choice of immediate therapy. The study of the chemical composition in human breath using gas chromatography/mass spectrometry (GC/MS) has shown a correlation...

Development of new treatments for metabolic bone disease, and evaluation of the effectiveness of existing therapies in individual patients, are severely hampered by the lack of any reliable tool for quickly measuring changes in bone mineral balance in...

NASA has patented a new technology called the Vision Chip, an implantable device that has the potential to restore or supplement visual function in a diseased or damaged retina. This technology could benefit millions of people in the US and globally who suffer from degenerative diseases of the eye’s...

Development of biosensors is an active field due to a wide range of applications in lab-on-a-chip, diagnostics of infectious diseases, cancer diagnostics, environment monitoring, biodetection, and others. One of the strategies used for selective identification of a target is to preselect a probe...

Monitoring colon health and transformation into a diseased tissue, including inflammation and cancer, is difficult using conventional techniques, as individuals are required to undergo invasive procedures. However, by using exfoliated cells, it is...

Knowledge of a patient’s cardiac age, or “heart age,” could prove useful to both patients and physicians for encouraging lifestyle changes that are potentially beneficial for cardiovascular health. This may be particularly true for patients who exhibit symptoms, but who test negative for cardiac...

The Time Series Product Tool (TSPT) is a MATLAB-based software application that computes and displays high-quality vegetation and environmental monitoring indices from high temporal revisit rate Moderate resolution Imaging Spectroradiometer (MODIS) and other satellite sensors. The original purpose of the...

There are eight herpes viruses that infect humans, causing a wide range of diseases resulting in considerable morbidity and associated costs. Varicella zoster virus (VZV) is a human herpes virus that causes chickenpox in children and shingles in adults. Approximately 1,000,000 new cases of...

Astronauts lose 1.0 to 1.5% of their bone mass per month on long-duration spaceflights. NASA wishes to monitor the bone loss onboard spacecraft to develop nutritional and exercise countermeasures, and make adjustments during long space missions. On Earth, the...

This software describes the transport and energy deposition of the passage of galactic cosmic rays in astronaut tissues during space travel, or heavy ion beams in patients in cancer therapy. Space radiation risk is a probability distribution, and time-dependent biological events must be...

Among Americans over 80, who represent the fastest growing segment of the U.S. population, half are debilitated with a neurodegenerative disorder. Of this group, 5.4 million now have Alzheimer’s Disease, and according to recent data released by the Alzheimer’s Association, by...