High-Resolution Ophthalmic Ultrasound System for Ocular Structures

An ophthalmic ultrasound system evaluates ocular structures more clearly by providing images of all aspects of the anterior segment. It provides images of the eye and tissues around and behind the eye to determine the presence of pathology when doctors are prohibited from viewing it directly due to opacity of the cornea, lens, or the vitreous gel that fills the eye.

Posted in: Briefs, MDB, Briefs, Bio-Medical, Diagnostics, Medical, Imaging, Imaging and visualization, Imaging, Imaging and visualization, Body regions, Diagnosis
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Improved Devices for Collecting Sweat for Chemical Analysis

Improved devices have been proposed for collecting sweat for biochemical analysis — especially for determination of the concentration of Ca2+ ions in sweat as a measure of loss of Ca from bones. Unlike commercially available sweat-collection patches used previously in monitoring osteoporosis and in qualitative screening for some drugs, the proposed devices would not allow evaporation of the volatile chemical components (mostly water) of sweat. Moreover, the proposed devices would be designed to enable determination of the volumes of collected sweat. From these volumes and the quantities of Ca2+ and/or other analytes as determined by other means summarized below, one could determine the concentrations of the analytes in sweat.

Posted in: Briefs, MDB, TSP, Briefs, TSP, Bio-Medical, Medical, Patient Monitoring, Analysis methodologies, Medical equipment and supplies
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Post-Fragmentation Whole Genome Amplification-Based Method

This innovation is derived from a proprietary amplification scheme that is based upon random fragmentation of the genome into a series of short, overlapping templates. The resulting shorter DNA strands (

Posted in: Briefs, Bio-Medical, Medical, Biological sciences, Medical equipment and supplies, Pharmaceuticals, Test procedures
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Microwave Tissue Soldering for Immediate Wound Closure

A novel approach for the immediate sealing of traumatic wounds is under development. A portable microwave generator and handheld antenna are used to seal wounds, binding the edges of the wound together using a biodegradable protein sealant or “solder.” This method could be used for repairing wounds in emergency settings by restoring the wound surface to its original strength within minutes. This technique could also be utilized for sur-gical purposes involving solid visceral organs (i.e., liver, spleen, and kidney) that currently do not respond well to ordinary surgical procedures.

Posted in: Briefs, Bio-Medical, Medical, Antennas, Antennas, Medical equipment and supplies, Adhesives and sealants, Injuries, Radiation, Rescue and emergency vehicles and equipment
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Stress-Driven Selection of Novel Phenotypes

A process has been developed that can confer novel properties, such as metal resistance, to a host bacterium. This same process can also be used to produce RNAs and peptides that have novel properties, such as the ability to bind particular compounds. It is inherent in the method that the peptide or RNA will behave as expected in the target organism. Plasmid-born mini-gene libraries coding for either a population of combinatorial peptides or stable, artificial RNAs carrying random inserts are produced. These libraries, which have no bias towards any biological function, are used to transform the organism of interest and to serve as an initial source of genetic variation for stress-driven evolution.

Posted in: Briefs, Bio-Medical, Medical, Biological sciences
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Principles, Techniques, and Applications of Tissue Microfluidics

The principle of tissue microfluidics and its resultant techniques has been applied to cell analysis. Building microfluidics to suit a particular tissue sample would allow the rapid, reliable, inexpensive, highly parallelized, selective extraction of chosen regions of tissue for purposes of further biochemical analysis. Furthermore, the applicability of the techniques ranges beyond the described pathology application. For example, they would also allow the posing and successful answering of new sets of questions in many areas of fundamental research.

Posted in: Briefs, Bio-Medical, Medical, Medical, health, and wellness, Research and development
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Robotic Scaffolds for Tissue Engineering and Organ Growth

The aim of tissue engineering (TE) is to restore tissue and organ functions with minimal host rejection. TE is seen as a future solution to solve the crisis of donor organs for transplant, which faces a shortage expected only to increase in the future. In this innovation, a flexible and configurable scaffold has been conceived that mechanically stresses cells that are seeded on it, stimulating them to increased growth.

Posted in: Briefs, Bio-Medical, Medical, Anatomy, Prostheses and implants, Robotics, Biomaterials, Nanotechnology
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Meet Our Readers: Michael Hudspeth, CAD Designer, Medical Devices

In a new series, the editors of NASA Tech Briefs magazine catch up with everyday engineers about their unique responsibilities and challenges. This week, we highlight fellow reader and CAD designer of medical devices, Michael Hudspeth.

Posted in: Articles, Medical, CAD / CAM / CAE, CAD, CAM, and CAE, Medical equipment and supplies, People and personalities
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Brain Sensing Technology Provides Real-Time Diagnosis

Every 21 seconds, someone suffers a serious brain injury, including stroke, trauma, or concussion. Until now, there has been no way to quickly and reliably diagnose these calamities.

Posted in: Briefs, MDB, Briefs, Bio-Medical, Medical, Patient Monitoring, Sensors, Software, Computer software / hardware, Computer software and hardware, Sensors and actuators, Computer software / hardware, Computer software and hardware, Sensors and actuators, Diagnosis, Diseases, Nervous system, Head injuries
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Principles, Techniques, and Applications of Tissue Microfluidics

The principle of tissue microfluidics and its resultant techniques has been applied to cell analysis. Building microfluidics to suit a particular tissue sample would allow the rapid, reliable, inexpensive, highly parallelized, selective extraction of chosen regions of tissue for purposes of further biochemical analysis. Furthermore, the applicability of the techniques ranges beyond the described pathology application. For example, they would also allow the posing and successful answering of new sets of questions in many areas of fundamental research.

Posted in: Briefs, MDB, TSP, Briefs, TSP, Bio-Medical, Medical, Patient Monitoring, Medical, health, and wellness, Research and development
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