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NASA Tech Briefs’ Bio-Medical Web page spotlights bio-medical technologies and product design ideas that have been published in NASA Tech Briefs magazine. This library of tech briefs pertains to the development and rollout of new bio-medical and life sciences technologies produced by NASA, its partners, and industry. Many of the Tech Briefs below are correlated to a Technical Support Package (TSP) or White Paper that can be downloaded free of charge.
May 2009
Droplet-Based Production of Liposomes

A process for making monodisperse liposomes having lipid bilayer membranes involves fewer, simpler process steps than do related prior methods. First, a microfluidic, cross-junction droplet generator is used to produce vesicles comprising aqueous-solution droplets contained in single-layer lipid membranes. The vesicles are collected in a lipid-solvent mix that is at ...
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Crashworthy Seats Would Afford Superior Protection

Adjustments enable optimization of support for different body sizes and shapes.

Seats to prevent or limit crash injuries to astronauts aboard the crew vehicle of the Orion spacecraft are undergoing development. The design of these seats incorporates and goes beyond crash-protection concepts embodied in prior spacecraft and racing-car ...
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Identifying and Inactivating Bacterial Spores

Problems associated with, and new strategies for, inactivating resistant organisms like Bacillus canaveralius (found at Kennedy Space Center during a survey of three NASA cleanrooms) have been defined. Identifying the particular component of the spore that allows its heightened resistance can guide the development of sterilization procedures that are targeted ...
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Microfluidic Extraction of Biomarkers Using Water as Solvent

Terahertz modulation of permittivity of water would enable solvation of molecules of interest.

A proposed device, denoted a miniature microfluidic biomarker extractor (μ-EX), would extract trace amounts of chemicals of interest from samples, such as soils and rocks. Traditionally, such extractions are performed on a large scale with ...
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Trans-Skull Ultrasound Scanner for Diagnosis of Rhino-Sinusitis

This system eliminates the need for CT or x-ray imaging.

Rhino-sinusitis, or sinus infection, is an inflammation of the paranasal sinuses, which can be caused by different conditions (bacterial, fungal, viral, allergic, or autoimmune). Bacterial rhino-sinusitis is currently assessed by puncture or imaging techniques (x-ray or CT) in ...
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Convergence Nanoparticles for Multi-Modal Biomedical Imaging

This technique enables detection, sensing, navigation, and actuation in a single nanosystem.

A project is underway to develop a novel, versatile, multi-functional convergence nanoparticle system that utilizes inorganic nanoparticles for advanced biomedical applications. Inorganic nanoparticles exhibit improved optical, magnetic, and electronic properties compared to classical bulk materials, making ...
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Microwell Arrays for Studying Many Individual Cells

“Laboratory-on-a-chip” devices that enable the simultaneous culturing and interrogation of many individual living cells have been invented. Each such device includes a silicon nitride-coated silicon chip containing an array of micromachined wells sized so that each well can contain one cell in contact or proximity with a patch clamp or ...
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Microfluidic Mixing Technology for a Universal Health Sensor

A highly efficient means of microfluidic mixing has been created for use with the rHEALTH sensor — an elliptical mixer and passive curvilinear mixing patterns. The rHEALTH sensor provides rapid, handheld, complete blood count, cell differential counts, electrolyte measurements, and other lab tests based on a reusable, flow-based microfluidic platform.
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Open-Access, Low-Magnetic-Field MRI System for Lung Research

An open-access magnetic resonance imaging (MRI) system is being developed for use in research on orientational/ gravitational effects on lung physiology and function. The open-access geometry enables study of human subjects in diverse orientations. This system operates at a magnetic flux density, considerably smaller than the flux densities of typical ...
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Use of Atomic Oxygen for Increased Water Contact Angles of Various Polymers for Biomedical Applications

Improved polymer hydrophilicity is beneficial for cell culturing and implant growth.

The purpose of this study was to determine the effect of atomic oxygen (AO) exposure on the hydrophilicity of nine different polymers for biomedical applications. Atomic oxygen treatment can alter the chemistry and morphology of polymer surfaces, ...
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Chemically Assisted Photocatalytic Oxidation System

The chemically assisted photocatalytic oxidation system (CAPOS) has been proposed for destroying micro-organisms and organic chemicals that may be suspended in the air or present on surfaces of an air-handling system that ventilates an indoor environment. The CAPOS would comprise an upstream and a downstream stage that would implement a ...
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Further Development of Scaffolds for Regeneration of Nerves

Scale-up toward clinically significant dimensions has been partially completed.

Progress has been made in continuing research on scaffolds for the guided growth of nerves to replace damaged ones. The scaffolds contain pores that are approximately cylindrical and parallel, with nearly uniform widths ranging from tens to hundreds of ...
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Identification of Bacteria and Determination of Biological Indicators

Identifying mechanisms of micro-organisms can prevent forward contamination in space missions and can help in developing new antibiotics and amino acids.

The ultimate goal of planetary protection research is to develop superior strategies for inactivating resistance-bearing micro-organisms like Rummelibacillus stabekisii. By first identifying the particular physiologic pathway and/ ...
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Wireless, Handheld Electronic Medical Record Application

Healthcare providers can view, update, and share patient information from a handheld device.

PocketChart™, available in numerous medical specialty editions, is a wireless, handheld electronic medical record application that will help physicians increase productivity, reduce transcription costs, and increase revenue through improved code levels. PocketChart enables a PocketPC ...
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Benchtop Antigen Detection Technique Using Nanofiltration and Fluorescent Dyes

This technique can help to monitor the quality of water by testing for contamination at restaurants, water treatment plants, and food processing plants.

The designed benchtop technique is primed to detect bacteria and viruses from antigenic surface marker proteins in solutions, initially water. This inclusive bio-immunoassay uniquely combines ...
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Isolation of Precursor Cells From Waste Solid Fat Tissue

A process for isolating tissue-specific progenitor cells exploits solid fat tissue obtained as waste from such elective surgical procedures as abdominoplasties (“tummy tucks”) and breast reductions. Until now, a painful and risky process of aspiration of bone marrow has been used to obtain a limited number of tissue-specific progenitor cells.
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Three-Dimensional Optical Coherence Tomography

Advantages over prior OCT systems include less bulk and greater speed.

Three-dimensional (3D) optical coherence tomography (OCT) is an advanced method of noninvasive infrared imaging of tissues in depth. Heretofore, commercial OCT systems for 3D imaging have been designed principally for external ophthalmological examination. As explained below, such ...
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Biomedical Wireless Ambulatory Crew Monitor

A compact, ambulatory biometric data acquisition system has been developed for space and commercial terrestrial use. BioWATCH (Bio medical Wireless and Ambulatory Telemetry for Crew Health) acquires signals from bio-medical sensors using acquisition modules attached to a common data and power bus. Several slots allow the user to configure the ...
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Apr 2009
Using Fluorescent Viruses for Detecting Bacteria in Water
Anaerobic Digestion in a Flooded Densified Leachbed
Mar 2009
Continuous-Flow System Produces Medical-Grade Water
Discrimination of Spore-Forming Bacilli Using spoIVA
Jan 2009
Sensitive, Rapid Detection of Bacterial Spores
Adenosine Monophosphate-Based Detection of Bacterial Spores
Oct 2008
Detecting Phycocyanin-Pigmented Microbes in Reflected Light
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