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Monitoring and Visualizing Brain Activity in Real-time During Brain Surgery

Watch this video to learn more about a thin film that combines an electrode grid and LEDs to both track and produce a visual representation of the brain’s activity in real-time during surgery.

“Neurosurgeons could see and stop a seizure before it spreads, view what brain areas are involved in different cognitive processes, and visualize the functional extent of tumor spread. This work will provide a powerful tool for the difficult task of removing a tumor from the most sensitive brain areas,” said Daniel Cleary  , one of the study’s coauthors, a neurosurgeon and assistant professor at Oregon Health and Science University.

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    00:00:00 during brain surgery electrical or functional mapping with electrode grids is applied to Define brain areas that control critical functions and cannot be removed the grids used in functional mapping in the operating room are thick and therefore do not conform to the curvy surface of the brain these clinical grids have sparse contacts that under sample the brain

    00:00:23 activity additionally these procedures rely on verbal interactions between the neurosurgeon and the electrophysiologist across the operating room healthy and diseased brain regions are then marked with sterile papers in order to Define reection margins for a safe surgery a team from UCSD integrated electronics and bio interfaces laboratory IBL led by Professor Shadi da

    00:00:48 at UC San Diego including Professor young bin Cho who was a postdoc in the DA's lab and is now an assistant professor at Olsen National Institute of Science and Technology in South Korea and Professor Sydney Cash's lab of Massachusetts General Hospital invented an intracranial electroen ieeg micro display that consists of

    00:01:12 freestanding arrays of 248 gallium nitride light emitting diodes laminated on the back of micro electrocorticography grids when laminated on the brain surface the UCSD ieeg micro display can record and display Spa ially corresponding light patterns on the surface of the brain in the surgical field this technology Builds on two significant advances by

    00:01:38 the team and their collaborators including the Platinum nanor Rod grid applied in over 30 human subjects that reveal detailed neurodynamics of the brain activity during motor function and in epilepsy and arrays of freestanding gallium nitrite LEDs that leverage a patented fabrication process to embed the LEDs in flexible and biocompatible film

    00:02:01 the resolution can be unprecedented revealing individual functional units across species such as the whisker barrels that represent individual whiskers in the rodent brain to enable richer and more nuanced visual representation of neural activity patterns the team printed indium phosphide quantum dot color conversion ink on the surface of the micro LEDs to

    00:02:26 display normal brain activity in one color and diseased brain activity in another the ieg micro display presents boundaries with submillimeter resolution the UCSD ieg micro display holds promise to facilitate monitoring of pathological brain activity in clinical settings the work was supported by the National Institutes of Health primarily by Dia's NIH director's new

    00:02:53 innovator award titled bringing light to functional mapping in reective neurosurgery and in part by brain initiative NIH grants