Bat ASC2: A Potent Negative Regulator of Inflammasomes

Bats are special in their ability to live long and host many emerging viruses. Previous studies showed that bats have altered inflammasomes, which are central players in aging and infection. However, the role of inflammasome signaling in combating inflammatory diseases remains poorly understood. Watch this video to see what bats can teach us about co-existing with viruses and preventing severe disease.

“This suggests that the high-level activity of ASC2 is a key mechanism by which bats keep inflammation under control, with implications for their long lifespan and unique status as a reservoir for viruses,” explained Dr Matae Ahn , first author and co-corresponding author of the study.