University of Pennsylvania researchers have shown that 3D printed templates of filament networks can be used to rapidly create vasculature and improve the function of engineered living tissues.
Rather than trying to print a large volume of tissue and leave hollow channels for vasculature in a layer-by-layer approach, the team focused on the vasculature first and designed free-standing 3D filament networks in the shape of a vascular system that sat inside a mold. As in lost-wax casting, a technique that has been used to make sculptures for thousands of years, the team’s approach allowed for the mold and vascular template to be removed once the cells were added and formed a solid tissue enveloping the filaments.
With promising indications that their vascular networks will be compatible with all types of cells and gels, the team believes their 3D printing method will be a scalable solution for a wide variety of cell- and tissue-based applications because all organ vasculature follows similar architectural patterns.
Also: 3D printing gets real.
